BACKGROUND: Pin tract infection is a common complication of external fixation. An antiinfective external fixator pin might help to reduce the incidence of pin tract infection and improve pin fixation. METHODS: Stainless steel and titanium external fixator pins, with and without a lipid stabilized hydroxyapatite/chlorhexidine coating, were evaluated in a goat model. Two pins contaminated with an identifiable Staphylococcus aureus strain were inserted into each tibia of 12 goats. The pin sites were examined daily. On day 14, the animals were killed, and the pin tips cultured. Insertion and extraction torques were measured. RESULTS: Infection developed in 100% of uncoated pins, whereas coated pins demonstrated 4.2% infected, 12.5% colonized, and the remainder, 83.3%, had no growth (p < 0.01). Pin coating decreased the percent loss of fixation torque over uncoated pins (p = 0.04). CONCLUSION: These results demonstrate that the lipid stabilized hydroxyapatite/chlorhexidine coating was successful in decreasing infection and improving fixation of external fixator pins.
BACKGROUND: Pin tract infection is a common complication of external fixation. An antiinfective external fixator pin might help to reduce the incidence of pin tract infection and improve pin fixation. METHODS:Stainless steel and titanium external fixator pins, with and without a lipid stabilized hydroxyapatite/chlorhexidine coating, were evaluated in a goat model. Two pins contaminated with an identifiable Staphylococcus aureus strain were inserted into each tibia of 12 goats. The pin sites were examined daily. On day 14, the animals were killed, and the pin tips cultured. Insertion and extraction torques were measured. RESULTS:Infection developed in 100% of uncoated pins, whereas coated pins demonstrated 4.2% infected, 12.5% colonized, and the remainder, 83.3%, had no growth (p < 0.01). Pin coating decreased the percent loss of fixation torque over uncoated pins (p = 0.04). CONCLUSION: These results demonstrate that the lipid stabilized hydroxyapatite/chlorhexidine coating was successful in decreasing infection and improving fixation of external fixator pins.
Authors: Tom Schmidt-Braekling; Arne Streitbuerger; Georg Gosheger; Friedrich Boettner; Markus Nottrott; Helmut Ahrens; Ralf Dieckmann; Wiebke Guder; Dimosthenis Andreou; Gregor Hauschild; Burkhard Moellenbeck; Wenzel Waldstein; Jendrik Hardes Journal: Eur J Orthop Surg Traumatol Date: 2017-03-06
Authors: Martin Gathen; Milena Maria Ploeger; Max Jaenisch; Sebastian Koob; Davide Cucchi; Adnan Kasapovic; Thomas Randau; Richard Placzek Journal: J Mater Sci Mater Med Date: 2019-11-08 Impact factor: 3.896
Authors: Adam Em Eltorai; Jack Haglin; Sudheesha Perera; Bielinsky A Brea; Roy Ruttiman; Dioscaris R Garcia; Christopher T Born; Alan H Daniels Journal: World J Orthop Date: 2016-06-18
Authors: Mirjam Lilja; Jan Henrik Sörensen; Ulrika Brohede; Maria Astrand; Philip Procter; Jörg Arnoldi; Hartwig Steckel; Maria Strømme Journal: J Mater Sci Mater Med Date: 2013-06-19 Impact factor: 3.896