Literature DB >> 11425950

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations.

A T Portman1, N Giladi, K L Leenders, P Maguire, L Veenma-van der Duin, J Swart, J Pruim, E S Simon, S Hassin-Baer, A D Korczyn.   

Abstract

Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.

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Year:  2001        PMID： 11425950     DOI： 10.1212/wnl.56.12.1759

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

1.  Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study.

Authors:  R N Alcalay; A Siderowf; R Ottman; E Caccappolo; H Mejia-Santana; M-X Tang; L Rosado; E Louis; D Ruiz; C Waters; S Fahn; L Cote; S Frucht; B Ford; M Orbe-Reilly; B Ross; M Verbitsky; S Kisselev; C Comella; A Colcher; D Jennings; M Nance; S Bressman; W K Scott; C Tanner; S Mickel; M Rezak; K E Novak; J H Friedman; R Pfeiffer; L Marsh; B Hiner; L N Clark; K Marder
Journal:  Neurology       Date:  2010-12-29       Impact factor: 9.910

2.  Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study.

Authors:  Karen S Marder; Ming X Tang; Helen Mejia-Santana; Llency Rosado; Elan D Louis; Cynthia L Comella; Amy Colcher; Andrew D Siderowf; Danna Jennings; Martha A Nance; Susan Bressman; William K Scott; Caroline M Tanner; Susan F Mickel; Howard F Andrews; Cheryl Waters; Stanley Fahn; Barbara M Ross; Lucien J Cote; Steven Frucht; Blair Ford; Roy N Alcalay; Michael Rezak; Kevin Novak; Joseph H Friedman; Ronald F Pfeiffer; Laura Marsh; Brad Hiner; Gregory D Neils; Miguel Verbitsky; Sergey Kisselev; Elise Caccappolo; Ruth Ottman; Lorraine N Clark
Journal:  Arch Neurol       Date:  2010-06

Review 3.  Significance of the parkin gene and protein in understanding Parkinson's disease.

Authors:  Paul S Fishman; George A Oyler
Journal:  Curr Neurol Neurosci Rep       Date:  2002-07       Impact factor: 5.081

4.  A multidisciplinary study of patients with early-onset PD with and without parkin mutations.

Authors:  E Lohmann; S Thobois; S Lesage; E Broussolle; S Tezenas du Montcel; M-J Ribeiro; P Remy; A Pelissolo; B Dubois; L Mallet; P Pollak; Y Agid; A Brice
Journal:  Neurology       Date:  2008-11-05       Impact factor: 9.910

5.  Genetics of Parkinson's disease.

Authors:  Thomas Gasser
Journal:  Dialogues Clin Neurosci       Date:  2004-09       Impact factor: 5.986

6.  In Silico Analysis of SNPs in PARK2 and PINK1 Genes That Potentially Cause Autosomal Recessive Parkinson Disease.

Authors:  Yousuf Hasan Yousuf Bakhit; Mohamed Osama Mirghani Ibrahim; Mutaz Amin; Yousra Abdelazim Mirghani; Mohamed Ahmed Salih Hassan
Journal:  Adv Bioinformatics       Date:  2016-12-29
  6 in total

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