Literature DB >> 11425555

Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation.

A Aviñó1, J C Morales, M Frieden, B G de la Torre, R G García, E Cubero, F J Luque, M Orozco, F Azorín, R Eritja.   

Abstract

We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure.

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Year:  2001        PMID： 11425555     DOI： 10.1016/s0960-894x(01)00295-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes.

Authors:  M Cristina de Almagro; Silvia Coma; Véronique Noé; Carlos J Ciudad
Journal:  J Biol Chem       Date:  2009-03-03       Impact factor: 5.157

2.  Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines.

Authors:  Anna Aviñó; Miriam Frieden; Juan Carlos Morales; Beatriz García de la Torre; Ramón Güimil García; Ferran Azorín; José Luis Gelpí; Modesto Orozco; Carlos González; Ramon Eritja
Journal:  Nucleic Acids Res       Date:  2002-06-15       Impact factor: 16.971

3.  Structural properties of g,t-parallel duplexes.

Authors:  Anna Aviñó; Elena Cubero; Raimundo Gargallo; Carlos González; Modesto Orozco; Ramon Eritja
Journal:  J Nucleic Acids       Date:  2010-02-21

4.  Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method.

Authors:  Laura G Carrascosa; S Gómez-Montes; A Aviñó; A Nadal; M Pla; R Eritja; L M Lechuga
Journal:  Nucleic Acids Res       Date:  2012-01-12       Impact factor: 16.971
  4 in total

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