Literature DB >> 11424082

Homeobox genes in normal and malignant cells.

C Cillo1, M Cantile, A Faiella, E Boncinelli.   

Abstract

Homeobox genes are transcription factors primarily involved in embryonic development. Several homeobox gene families have so far been identified: Hox, EMX, PAX, MSX as well as many isolated divergent homeobox genes. Among these, Hox genes are most intriguing for having a regulatory network structure organization. Recent indications suggest the involvement of homeobox genes in (i) crucial adult eukariotic cell functions and (ii) human diseases, spanning from diabetes to cancer. In this review we will discuss the mechanisms through which homeobox genes act, and will propose a model for the function of the Hox gene network as decoding system for achieving specific genetic programs. New technologies for whole-genome RNA expression will be crucial to evaluate the clinical relevance of homeobox genes in structural and metabolic diseases. Copyright 2001 Wiley-Liss, Inc.

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Mesh：

Year:  2001        PMID： 11424082     DOI： 10.1002/jcp.1115

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  63 in total

1.  Conference report--extracellular matrix and cancer: revisiting metalloproteinases highlights from the annual meeting of the American Society for Cell Biology; December 13-17, 2003; San Francisco, California.

Authors:  Sara M Mariani
Journal:  MedGenMed       Date:  2004-02-23

2.  Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome.

Authors:  Angela Di Vinci; Ida Casciano; Elena Marasco; Barbara Banelli; Gian Luigi Ravetti; Luana Borzì; Claudio Brigati; Alessandra Forlani; Alessandra Dorcaratto; Giorgio Allemanni; Gianluigi Zona; Renato Spaziante; Henning Gohlke; Giovanni Gardin; Domenico Franco Merlo; Vilma Mantovani; Massimo Romani
Journal:  J Cancer Res Clin Oncol       Date:  2011-09-27       Impact factor: 4.553

3.  Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells.

Authors:  Haiyan Lei; Aster H Juan; Moo-Sang Kim; Frank H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-22       Impact factor: 11.205

Review 4.  Uncovering the DNA methylome in chronic lymphocytic leukemia.

Authors:  Nicola Cahill; Richard Rosenquist
Journal:  Epigenetics       Date:  2013-01-15       Impact factor: 4.528

5.  Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.

Authors:  Luca Quagliata; Matthias S Matter; Salvatore Piscuoglio; Leila Arabi; Christian Ruiz; Alfredo Procino; Michal Kovac; Francesca Moretti; Zuzanna Makowska; Tujana Boldanova; Jesper B Andersen; Monika Hämmerle; Luigi Tornillo; Markus H Heim; Sven Diederichs; Clemente Cillo; Luigi M Terracciano
Journal:  Hepatology       Date:  2014-01-28       Impact factor: 17.425

6.  The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

Authors:  C Bonhomme; I Duluc; E Martin; K Chawengsaksophak; M-P Chenard; M Kedinger; F Beck; J-N Freund; C Domon-Dell
Journal:  Gut       Date:  2003-10       Impact factor: 23.059

7.  The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways.

Authors:  Carlos S Moreno
Journal:  Am J Pathol       Date:  2009-12-17       Impact factor: 4.307

8.  Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons.

Authors:  Stéphane Nédélec; Isabelle Foucher; Isabelle Brunet; Colette Bouillot; Alain Prochiantz; Alain Trembleau
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-09       Impact factor: 11.205

9.  The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way.

Authors:  Janneke de Wilde; Martijn F M Hulshof; Mark V Boekschoten; Philip de Groot; Egbert Smit; Edwin C M Mariman
Journal:  BMC Genomics       Date:  2010-03-15       Impact factor: 3.969

10.  Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6.

Authors:  Jörg Storre; Hans-Peter Elsässer; Miriam Fuchs; Diana Ullmann; David M Livingston; Stefan Gaubatz
Journal:  EMBO Rep       Date:  2002-07       Impact factor: 8.807
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