PATIENTS/ METHOD: Twenty-seven adults who underwent an orchidopexy before 2 years of age have recently had their spermiograms analyzed. RESULTS: Sixty-three percent of them had a normal sperm count; their germ cells had undergone the second stage of maturation and adult dark (Ad) spermatogonia were present at the time of surgery 20-25 years earlier. In contrast, 37% of them were infertile despite a seemingly successful orchidopexy; they had impaired second-step germ cell maturation and Ad spermatogonia were absent at orchidopexy. CONCLUSIONS: Transformation of gonocytes into Ad spermatogonia is crucial for fertility. This underscores the importance of a testicular biopsy at orchidopexy in order to identify those who could benefit from early LH-RH treatment after orchidopexy.
PATIENTS/ METHOD: Twenty-seven adults who underwent an orchidopexy before 2 years of age have recently had their spermiograms analyzed. RESULTS: Sixty-three percent of them had a normal sperm count; their germ cells had undergone the second stage of maturation and adult dark (Ad) spermatogonia were present at the time of surgery 20-25 years earlier. In contrast, 37% of them were infertile despite a seemingly successful orchidopexy; they had impaired second-step germ cell maturation and Ad spermatogonia were absent at orchidopexy. CONCLUSIONS: Transformation of gonocytes into Ad spermatogonia is crucial for fertility. This underscores the importance of a testicular biopsy at orchidopexy in order to identify those who could benefit from early LH-RH treatment after orchidopexy.
Authors: A Rose; H Sperling; J Steffens; G Lümmen; B Hauffa; D Rohrmann; S Conrad; P Hoyer; H Rübben Journal: Urologe A Date: 2006-09 Impact factor: 0.639
Authors: John M Hutson; Ruili Li; Bridget R Southwell; Bodil L Petersen; Jorgen Thorup; Dina Cortes Journal: Front Endocrinol (Lausanne) Date: 2013-01-03 Impact factor: 5.555