| Literature DB >> 11422138 |
S H Kim1, H Jeong, Y K Kim, S H Cho, K U Min, Y Y Kim.
Abstract
There have been few reported cases of occupational asthma induced by Pinellia ternata (Banha), and the mechanism responsible for this type of asthma is still undetermined. We report a case of Banha-induced occupational asthma with IgE-mediated mechanism. The patient had positive skin responses to Banha extract and Banha-specific bronchial challenge elicited an early asthmatic response. The serum-specific IgE binding to Banha extract was detectable and completely inhibited with the additions of 0.1 microg/mL of Banha extract on ELISA inhibition. Seven IgE binding components to Banha extract (6.5, 22, 24, 32, 34, and 48 kDa) were detected using SDS-PAGE and immunoblot analysis. In conclusion, the results of this study suggest that P. ternata (Banha)-derived allergens are able to cause IgE-mediated bronchoconstriction in exposed workers.Entities:
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Year: 2001 PMID： 11422138 DOI： 10.1046/j.1365-2222.2001.01067.x
Source DB: PubMed Journal: Clin Exp Allergy ISSN： 0954-7894 Impact factor: 5.018