Literature DB >> 11421284

Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism.

H W van Veen1, C F Higgins, W N Konings.   

Abstract

The elevated expression of ATP binding cassette (ABC) multidrug transporters in multidrug-resistant cells interferes with the drug-based control of cancers and infectious pathogenic microorganisms. Multidrug transporters interact directly with the drug substrates. This review summarizes current insights into the mechanism(s) by which ATP hydrolysis is coupled to drug transport in bacterial LmrA and its human homolog P-glycoprotein. In addition, the relevance of these insights for other ABC transporters will be discussed.

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Year:  2001        PMID： 11421284     DOI： 10.1016/s0923-2508(01)01208-6

Source DB:  PubMed          Journal:  Res Microbiol        ISSN： 0923-2508            Impact factor:   3.992


  9 in total

Review 1.  ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies.

Authors:  Helen S Garmory; Richard W Titball
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

2.  Class C ABC transporters and Saccharomyces cerevisiae vacuole fusion.

Authors:  Terry L Sasser; Rutilio A Fratti
Journal:  Cell Logist       Date:  2014-07-03

Review 3.  Multidrug resistance in bacteria.

Authors:  Hiroshi Nikaido
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

Review 4.  Structure, function, and evolution of bacterial ATP-binding cassette systems.

Authors:  Amy L Davidson; Elie Dassa; Cedric Orelle; Jue Chen
Journal:  Microbiol Mol Biol Rev       Date:  2008-06       Impact factor: 11.056

5.  The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites.

Authors:  Alena Siarheyeva; Frances J Sharom
Journal:  Biochem J       Date:  2009-04-15       Impact factor: 3.857

6.  Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets.

Authors:  Md Masud Parvege; Monzilur Rahman; Mohammad Shahnoor Hossain
Journal:  Drug Target Insights       Date:  2014-12-09

Review 7.  Drug resistance: from bacteria to cancer.

Authors:  Harsh Patel; Zhuo-Xun Wu; Yanglu Chen; Letao Bo; Zhe-Sheng Chen
Journal:  Mol Biomed       Date:  2021-09-10

8.  Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis.

Authors:  Peter P Borbat; Kavitha Surendhran; Marco Bortolus; Ping Zou; Jack H Freed; Hassane S Mchaourab
Journal:  PLoS Biol       Date:  2007-10       Impact factor: 8.029

Review 9.  Small and Innovative Molecules as New Strategy to Revert MDR.

Authors:  Laura Zinzi; Elena Capparelli; Mariangela Cantore; Marialessandra Contino; Marcello Leopoldo; Nicola Antonio Colabufo
Journal:  Front Oncol       Date:  2014-01-21       Impact factor: 6.244
  9 in total

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