| Literature DB >> 11415522 |
P A Underhill1, G Passarino, A A Lin, P Shen, M Mirazón Lahr, R A Foley, P J Oefner, L L Cavalli-Sforza.
Abstract
Although molecular genetic evidence continues to accumulate that is consistent with a recent common African ancestry of modern humans, its ability to illuminate regional histories remains incomplete. A set of unique event polymorphisms associated with the non-recombining portion of the Y-chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges. A total of 205 markers identified by denaturing high performance liquid chromatography (DHPLC), together with 13 taken from the literature, were used to construct a parsimonious genealogy. Ancestral allelic states were deduced from orthologous great ape sequences. A total of 131 unique haplotypes were defined which trace the microevolutionary trajectory of global modern human genetic diversification. The genealogy provides a detailed phylogeographic portrait of contemporary global population structure that is emblematic of human origins, divergence and population history that is consistent with climatic, paleoanthropological and other genetic knowledge.Entities:
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Year: 2001 PMID： 11415522 DOI： 10.1046/j.1469-1809.2001.6510043.x
Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670