The multiple organ dysfunction syndrome and late-phase mortality in sepsis.

Sepsis is a devastating and common syndrome characterized by systemic inflammation. Sepsis accounts for considerable morbidity and mortality among intensive care unit patients. Although the inflammatory response generated by the immune system represents the body's attempt to clear invading pathogens, it is the failure to modulate this response that leads to dysregulated inflammation and the injury of healthy tissue. A great deal of research has characterized many of the early events and mediators that lead to systemic inflammation and sepsis. However, substantially less is known about the pathogenesis of the late phase of sepsis, which accounts for the vast majority of sepsis-related mortality (ie, the dysfunction and subsequent failure of the major parenchymal organs).