Literature DB >> 11412974

Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

K Auclair1, J Kennedy, C R Hutchinson, J C Vederas.   

Abstract

Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin (1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L (3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastatin diketide synthase (lovF protein) does not require lovC.

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Year:  2001        PMID： 11412974     DOI： 10.1016/s0960-894x(01)00290-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Engineering Saccharomyces cerevisiae for production of simvastatin.

Authors:  Carly M Bond; Yi Tang
Journal:  Metab Eng       Date:  2018-09-10       Impact factor: 9.783

2.  LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

Authors:  Wei Xu; Yit-Heng Chooi; Jin W Choi; Shuang Li; John C Vederas; Nancy A Da Silva; Yi Tang
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-07       Impact factor: 15.336

Review 3.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

4.  Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

Authors:  Brian D Ames; Chi Nguyen; Joel Bruegger; Peter Smith; Wei Xu; Suzanne Ma; Emily Wong; Steven Wong; Xinkai Xie; Jesse W-H Li; John C Vederas; Yi Tang; Shiou-Chuan Tsai
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

5.  FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

Authors:  Michael J Meehan; Xinkai Xie; Xiling Zhao; Wei Xu; Yi Tang; Pieter C Dorrestein
Journal:  Biochemistry       Date:  2010-12-22       Impact factor: 3.162

6.  Microbial production and biomedical applications of lovastatin.

Authors:  A Seenivasan; S Subhagar; R Aravindan; T Viruthagiri
Journal:  Indian J Pharm Sci       Date:  2008-11       Impact factor: 0.975

7.  Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin.

Authors:  Sietske Grijseels; Carsten Pohl; Jens Christian Nielsen; Zahida Wasil; Yvonne Nygård; Jens Nielsen; Jens C Frisvad; Kristian Fog Nielsen; Mhairi Workman; Thomas Ostenfeld Larsen; Arnold J M Driessen; Rasmus John Normand Frandsen
Journal:  Fungal Biol Biotechnol       Date:  2018-12-19
  7 in total

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