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Literature DB >> 11408248

Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma.

H L Jordan¹, A S Pereira, M S Cohen, A D Kashuba.

Abstract

To establish whether a feline model can predict nucleoside analogue behavior in human semen, zidovudine (ZDV) and lamivudine (3TC) pharmacokinetic parameters (PKs) were determined in the blood and seminal plasma of healthy cats. Our results show considerable similarity in ZDV and 3TC PKs between cats and humans. As in humans, ZDV and 3TC tend to accumulate in feline seminal plasma. Area under the blood plasma concentration-time curve was predictive of seminal plasma excretion. The felid model offers a unique in vivo experimental alternative for investigating the pharmacokinetics of nucleoside analogues in the male genital tract.

Entities: Chemical Species

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Year: 2001 PMID： 11408248 PMCID： PMC90625 DOI： 10.1128/AAC.45.7.2173-2176.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

32 in total

Review 1. Antiretroviral therapy: state of the HAART.

Authors: S Vella; L Palmisano
Journal: Antiviral Res Date: 2000-01 Impact factor: 5.970

Review 2. Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.

Authors: A D Kashuba; J R Dyer; L M Kramer; R H Raasch; J J Eron; M S Cohen
Journal: Antimicrob Agents Chemother Date: 1999-08 Impact factor: 5.191

3. Poor penetration of the male genital tract by HIV-1 protease inhibitors.

Authors: S Taylor; D J Back; J Workman; S M Drake; D J White; B Choudhury; P A Cane; G M Beards; K Halifax; D Pillay
Journal: AIDS Date: 1999-05-07 Impact factor: 4.177

4. Single-dose pharmacokinetics and safety of abacavir (1592U89), zidovudine, and lamivudine administered alone and in combination in adults with human immunodeficiency virus infection.

Authors: L H Wang; G E Chittick; J A McDowell
Journal: Antimicrob Agents Chemother Date: 1999-07 Impact factor: 5.191

5. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.

Authors: A S Pereira; A D Kashuba; S A Fiscus; J E Hall; R R Tidwell; L Troiani; J A Dunn; J J Eron; M S Cohen
Journal: J Infect Dis Date: 1999-12 Impact factor: 5.226

6. Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry.

Authors: A S Pereira; K B Kenney; M S Cohen; J E Hall; J J Eron; R R Tidwell; J A Dunn
Journal: J Chromatogr B Biomed Sci Appl Date: 2000-05-26

7. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial.

Authors: L A Guay; P Musoke; T Fleming; D Bagenda; M Allen; C Nakabiito; J Sherman; P Bakaki; C Ducar; M Deseyve; L Emel; M Mirochnick; M G Fowler; L Mofenson; P Miotti; K Dransfield; D Bray; F Mmiro; J B Jackson
Journal: Lancet Date: 1999-09-04 Impact factor: 79.321

8. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms.

Authors: M H Court; D J Greenblatt
Journal: Pharmacogenetics Date: 2000-06

Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma.

Review 1. Antiretroviral therapy: state of the HAART.

Review 2. Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.

3. Poor penetration of the male genital tract by HIV-1 protease inhibitors.

4. Single-dose pharmacokinetics and safety of abacavir (1592U89), zidovudine, and lamivudine administered alone and in combination in adults with human immunodeficiency virus infection.

5. Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.

6. Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry.

7. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial.

8. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms.

Review 9. Clinical pharmacokinetics of lamivudine.

10. Feline bone marrow transplantation: its use in FIV-infected cats.

1. Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review.

Review 2. Antiretroviral bioanalysis methods of tissues and body biofluids.