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Literature DB >> 11403818

Congestive heart failure associated with itraconazole.

Abstract

Itraconazole is a synthetic antifungal agent approved in the USA for the treatment of onychomycosis and serious systemic fungal infections. Animal and clinical pharmacology studies suggest negative inotropic effects with itraconazole. Data from the US Food and Drug Administration's Adverse Event Reporting System suggest that use of itraconazole is associated with congestive heart failure. We summarise the details of 58 cases suggestive of congestive heart failure in association with the use of itraconazole. Labelling of itraconazole has been changed to alert physicians to this new finding.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2001 PMID： 11403818 DOI： 10.1016/S0140-6736(00)04891-1

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

28 in total

1. Adverse drug event monitoring at the Food and Drug Administration.

Authors: Syed Rizwanuddin Ahmad
Journal: J Gen Intern Med Date: 2003-01 Impact factor: 5.128

2. Primary cutaneous blastomycosis as a cause of acute respiratory distress syndrom: case report and literature review.

Authors: Jason J Emer; Joel B Spear
Journal: J Clin Aesthet Dermatol Date: 2009-03

3. Cardiotoxicity with Itraconazole.

Authors: Vishesh Paul; Harsh Rawal
Journal: BMJ Case Rep Date: 2017-04-10

4. Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignancies.

Authors: Gloria N Mattiuzzi; Gladys Alvarado; Francis J Giles; Luis Ostrosky-Zeichner; Jorge Cortes; Susan O'brien; Srdan Verstovsek; Stefan Faderl; Xian Zhou; Issam I Raad; B Nebiyou Bekele; G J Leitz; Ivonne Lopez-Roman; Elihu H Estey
Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

Congestive heart failure associated with itraconazole.

1. Adverse drug event monitoring at the Food and Drug Administration.

2. Primary cutaneous blastomycosis as a cause of acute respiratory distress syndrom: case report and literature review.

3. Cardiotoxicity with Itraconazole.

4. Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignancies.

Review 5. Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients.

6. Invasive fungal infections in acute leukemia.

Review 7. Heart failure induced by non-cardiac drugs.

Review 8. Current concepts in antifungal pharmacology.

9. Nanosuspension formulation of itraconazole eliminates the negative inotropic effect of SPORANOX in dogs.

10. The role of second-generation antifungal triazoles for treatment of the endemic mycoses.