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Literature DB >> 11403625

Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors.

N L Pohl¹, M Hans, H Y Lee, Y S Kim, D E Cane, C Khosla.

Abstract

Entities: Chemical Gene

Mesh：

Substances：

Year: 2001 PMID： 11403625 DOI： 10.1021/ja0028368

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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13 in total

1. Structure-guided expansion of the substrate range of methylmalonyl coenzyme A synthetase (MatB) of Rhodopseudomonas palustris.

Authors: Heidi A Crosby; Katherine C Rank; Ivan Rayment; Jorge C Escalante-Semerena
Journal: Appl Environ Microbiol Date: 2012-07-06 Impact factor: 4.792

Review 2. Total (bio)synthesis: strategies of nature and of chemists.

Authors: Alexandra A Roberts; Katherine S Ryan; Bradley S Moore; Tobias A M Gulder
Journal: Top Curr Chem Date: 2010

Review 3. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

Authors: Briana J Dunn; Chaitan Khosla
Journal: J R Soc Interface Date: 2013-05-29 Impact factor: 4.118

4. Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.

Authors: Anna Lechner; Micheal C Wilson; Yeon Hee Ban; Jae-Yeon Hwang; Yeo Joon Yoon; Bradley S Moore
Journal: ACS Synth Biol Date: 2012-11-05 Impact factor: 5.110

5. Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase.

Authors: Dominique Padovani; Ruma Banerjee
Journal: Biochemistry Date: 2006-03-07 Impact factor: 3.162

6. Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase.

Authors: Steven O Mansoorabadi; Rugmini Padmakumar; Nisso Fazliddinova; Monica Vlasie; Ruma Banerjee; George H Reed
Journal: Biochemistry Date: 2005-03-08 Impact factor: 3.162

Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors.

1. Structure-guided expansion of the substrate range of methylmalonyl coenzyme A synthetase (MatB) of Rhodopseudomonas palustris.

Review 2. Total (bio)synthesis: strategies of nature and of chemists.

Review 3. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

4. Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering.

5. Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase.

6. Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase.

7. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.

Review 8. Metabolic engineering of carbon and redox flow in the production of small organic acids.

9. Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci.

Review 10. Steps towards the synthetic biology of polyketide biosynthesis.