Literature DB >> 11401476

Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene.

S Aoki1, K Higuchi, N Isozumi, K Matsui, Y Miyamoto, N Itoh, K Tanaka, M Kobayashi.   

Abstract

Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.1-5 microg/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells. Copyright 2001 Academic Press.

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Year:  2001        PMID： 11401476     DOI： 10.1006/bbrc.2001.4588

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.

Authors:  Jingqiu Dai; Yang Liu; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2007-10-25       Impact factor: 4.050

Review 2.  Targeting cancer with sesterterpenoids: the new potential antitumor drugs.

Authors:  Caiguo Zhang; Yan Liu
Journal:  J Nat Med       Date:  2015-04-19       Impact factor: 2.343

3.  12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77.

Authors:  Mi Zhou; Bo-Rong Peng; Wenjing Tian; Jui-Hsin Su; Guanghui Wang; Ting Lin; Dequan Zeng; Jyh-Horng Sheu; Haifeng Chen
Journal:  Mar Drugs       Date:  2020-07-21       Impact factor: 5.118

4.  Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.

Authors:  Inho Yang; Jusung Lee; Jihye Lee; Dongyup Hahn; Jungwook Chin; Dong Hwan Won; Jaeyoung Ko; Hyukjae Choi; Ahreum Hong; Sang-Jip Nam; Heonjoong Kang
Journal:  Molecules       Date:  2018-12-03       Impact factor: 4.411

5.  Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells.

Authors:  Dexin Kong; Shunji Aoki; Yoshihiro Sowa; Toshiyuki Sakai; Motomasa Kobayashi
Journal:  Mar Drugs       Date:  2008-08-26       Impact factor: 5.118

Review 6.  Marine Sponge Natural Products with Anticancer Potential: An Updated Review.

Authors:  Cinzia Calcabrini; Elena Catanzaro; Anupam Bishayee; Eleonora Turrini; Carmela Fimognari
Journal:  Mar Drugs       Date:  2017-10-13       Impact factor: 5.118
  6 in total

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