Literature DB >> 11396185

The antiproliferative effect of coumarins on several cancer cell lines.

S Kawaii1, Y Tomono, K Ogawa, M Sugiura, M Yano, Y Yoshizawa.   

Abstract

Twenty-one coumarins were examined for their antiproliferative activity towards several cancer cell lines, namely lung carcinoma (A549), melanin pigment producing mouse melanoma (B16 melanoma 4A5), human T-cell leukemia (CCRF-HSB-2), and human gastric cancer, lymph node metastasized (TGBC11TKB). The structure-activity relationship established from the results revealed that the 6,7-dihydroxy moiety had an important role for their antiproliferative activity. Analysis of cell cycle distribution indicated that esculetin-treated cells accumulated in the G1 (at 400 microM) or in S phase (at 100 microM).

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Year:  2001        PMID： 11396185

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  10 in total

1.  (7-Chloro-2-oxo-2H-chromen-4-yl)methyl pyrrolidine-1-carbodi-thio-ate.

Authors:  O Kotresh; H C Devarajegowda; Arunkumar Shirahatti; K Mahesh Kumar; N M Mahabhaleshwaraiah
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-10-23

2.  Crystal structure of (7-methyl-2-oxo-2H-chromen-4-yl)methyl piperidine-1-carbo-di-thio-ate.

Authors:  K R Roopashree; T G Meenakshi; K Mahesh Kumar; O Kotresh; H C Devarajegowda
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-29

Review 3.  Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use.

Authors:  Anik Boudreau; Allison J Richard; Innocence Harvey; Jacqueline M Stephens
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-08       Impact factor: 5.555

4.  New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents.

Authors:  Irena Kostova; Georgi Momekov; Peya Stancheva
Journal:  Met Based Drugs       Date:  2007

5.  Reduced paxillin expression contributes to the antimetastatic effect of 4-hydroxycoumarin on B16-F10 melanoma cells.

Authors:  Marco A Velasco-Velázquez; Nohemí Salinas-Jazmín; Nicandro Mendoza-Patiño; Juan J Mandoki
Journal:  Cancer Cell Int       Date:  2008-05-20       Impact factor: 5.722

6.  Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism.

Authors:  Noor Shahirah Suparji; Gomathi Chan; Hani Sapili; Norhafiza M Arshad; Lionel L A In; Khalijah Awang; Noor Hasima Nagoor
Journal:  PLoS One       Date:  2016-03-14       Impact factor: 3.240

7.  Attenuation of doxorubicin-induced cardiotoxicity by esculetin through modulation of Bmi-1 expression.

Authors:  Fan Xu; Xiao Li; Lanfang Liu; Xu Xiao; Li Zhang; Shenglin Zhang; Pingping Lin; Xiaojie Wang; Yongwei Wang; Qingshan Li
Journal:  Exp Ther Med       Date:  2017-07-10       Impact factor: 2.447

8.  Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1.

Authors:  Rashi Arora; Sharad Sawney; Vikas Saini; Chris Steffi; Manisha Tiwari; Daman Saluja
Journal:  Mol Cancer       Date:  2016-10-18       Impact factor: 27.401

9.  Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain.

Authors:  María Rubín-García; Facundo Vitelli-Storelli; Antonio José Molina; Raúl Zamora-Ros; Nuria Aragonés; Eva Adarnaz; Gemma Castaño-Vinyals; Mireia Obón-Santacana; Inés Gómez-Acebo; Ana Molina-Barceló; Guillermo Fernández-Tardón; José J Jiménez-Moleón; Juan Alguacil; María Dolores Chirlaque; Estefanía Toledo; Beatriz Pérez-Gómez; Marina Pollán; Manolis Kogevinas; Vicente Martín
Journal:  Nutrients       Date:  2020-10-26       Impact factor: 5.717

10.  Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial-Mesenchymal Transition and Migration in A549 Cells.

Authors:  Rodrigo Santos Aquino de Araújo; Julianderson de Oliveira Dos Santos Carmo; Simone Lara de Omena Silva; Camila Radelley Azevedo Costa da Silva; Tayhana Priscila Medeiros Souza; Natália Barbosa de Mélo; Jean-Jacques Bourguignon; Martine Schmitt; Thiago Mendonça de Aquino; Renato Santos Rodarte; Ricardo Olímpio de Moura; José Maria Barbosa Filho; Emiliano Barreto; Francisco Jaime Bezerra Mendonça-Junior
Journal:  Pharmaceuticals (Basel)       Date:  2022-01-17
  10 in total

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