| Literature DB >> 11392614 |
M U Gillette1, G F Buchanan, L Artinian, S E Hamilton, N M Nathanson, C Liu.
Abstract
Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.Mesh：
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Year: 2001 PMID： 11392614 DOI： 10.1016/s0024-3205(01)01040-2
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037