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Literature DB >> 11390631

Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis.

Y Gwack¹, S Hwang, H Byun, C Lim, J W Kim, E J Choi, J Choe.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle.

Entities: Gene Species

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Year: 2001 PMID： 11390631 PMCID： PMC114345 DOI： 10.1128/JVI.75.13.6245-6248.2001

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

18 in total

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5. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50.

Authors: Y Gwack; H Byun; S Hwang; C Lim; J Choe
Journal: J Virol Date: 2001-02 Impact factor: 5.103

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Journal: J Virol Date: 1999-11 Impact factor: 5.103

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20 in total

Review 1. Molecular biology of KSHV in relation to AIDS-associated oncogenesis.

Authors: Whitney Greene; Kurt Kuhne; Fengchun Ye; Jiguo Chen; Fuchun Zhou; Xiufen Lei; Shou-Jiang Gao
Journal: Cancer Treat Res Date: 2007

Review 2. Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.

Authors: Qiliang Cai; Suhbash C Verma; Jie Lu; Erle S Robertson
Journal: Adv Virus Res Date: 2010 Impact factor: 9.937

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Journal: J Virol Date: 2005-05 Impact factor: 5.103

Review 4. Why do viruses cause cancer? Highlights of the first century of human tumour virology.

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Journal: Nat Rev Cancer Date: 2010-11-24 Impact factor: 60.716

Review 5. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis.

Authors: Lyubomir A Dourmishev; Assen L Dourmishev; Diana Palmeri; Robert A Schwartz; David M Lukac
Journal: Microbiol Mol Biol Rev Date: 2003-06 Impact factor: 11.056