Literature DB >> 11389843

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.

M L Mayer1, S P Gygi, R Aebersold, P Hieter.   

Abstract

We have identified and characterized an alternative RFC complex RFC(Ctf18p, Ctf8p, Dcc1p) that is required for sister chromatid cohesion and faithful chromosome transmission. Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p, and Rfc5p but not with Rfc1p or Rad24p. Deletion of CTF18, CTF8, or DCC1 singly or in combination (ctf18Deltactf8Deltadcc1Delta) leads to sensitivity to microtubule depolymerizing drugs and a severe sister chromatid cohesion defect. Furthermore, temperature-sensitive mutations in RFC4 result in precocious sister chromatid separation. Our results highlight a novel function of the RFC proteins and support a model in which sister chromatid cohesion is established at the replication fork via a polymerase switching mechanism and a replication-coupled remodeling of chromatin.

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Year:  2001        PMID： 11389843     DOI： 10.1016/s1097-2765(01)00254-4

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  160 in total

Review 1.  Evidence that replication fork components catalyze establishment of cohesion between sister chromatids.

Authors:  D R Carson; M F Christman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

2.  Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.

Authors:  K Tanaka; Z Hao; M Kai; H Okayama
Journal:  EMBO J       Date:  2001-10-15       Impact factor: 11.598

3.  Purification and characterization of human DNA damage checkpoint Rad complexes.

Authors:  L A Lindsey-Boltz; V P Bermudez; J Hurwitz; A Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

4.  S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

Authors:  Cheryl D Warren; D Mark Eckley; Marina S Lee; Joseph S Hanna; Adam Hughes; Brian Peyser; Chunfa Jie; Rafael Irizarry; Forrest A Spencer
Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

5.  Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

Authors:  Vladimir P Bermudez; Laura A Lindsey-Boltz; Anthony J Cesare; Yoshimasa Maniwa; Jack D Griffith; Jerard Hurwitz; Aziz Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-10       Impact factor: 11.205

6.  Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process.

Authors:  Ceslovas Venclovas; Michael E Colvin; Michael P Thelen
Journal:  Protein Sci       Date:  2002-10       Impact factor: 6.725

7.  The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae.

Authors:  Bernhard Suter; Amy Tong; Michael Chang; Lisa Yu; Grant W Brown; Charles Boone; Jasper Rine
Journal:  Genetics       Date:  2004-06       Impact factor: 4.562

Review 8.  From a single double helix to paired double helices and back.

Authors:  Kim Nasmyth; Alexander Schleiffer
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2004-01-29       Impact factor: 6.237

9.  Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion.

Authors:  Mong Sing Lai; Masayuki Seki; Ayako Ui; Takemi Enomoto
Journal:  EMBO Rep       Date:  2007-06-15       Impact factor: 8.807

10.  A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication.

Authors:  Yanjiao Zhou; Teresa S-F Wang
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272
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