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Literature DB >> 11389465

Mechanisms of transcriptional memory.

Abstract

How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.

Entities: Gene Species

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Year: 2001 PMID： 11389465 DOI： 10.1038/35073039

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

121 in total

1. A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development.

Authors: Cédric Maurange; Renato Paro
Journal: Genes Dev Date: 2002-10-15 Impact factor: 11.361

2. A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion.

Authors: Eric M Balicky; Lynn Young; Terry L Orr-Weaver; Sharon E Bickel
Journal: Chromosoma Date: 2003-12-11 Impact factor: 4.316

3. GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.

Authors: Boris A Leibovitch; Quinn Lu; Lawrence R Benjamin; Yingyun Liu; David S Gilmour; Sarah C R Elgin
Journal: Mol Cell Biol Date: 2002-09 Impact factor: 4.272

Mechanisms of transcriptional memory.

1. A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development.

2. A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion.

3. GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter.

4. GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element.

5. Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets.

6. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.

Review 7. Epigenetic modifications in pluripotent and differentiated cells.

8. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

Review 9. Role of chromatin states in transcriptional memory.

10. Arabidopsis MSI1 is a component of the MEA/FIE Polycomb group complex and required for seed development.