Literature DB >> 11383489

A safety-catch linker for amine release under biologically compatible conditions.

D Orain1, M Bradley.   

Abstract

A 'biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

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Year:  2000        PMID： 11383489     DOI： 10.1023/a:1011355300910

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  2 in total

1.  Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase.

Authors:  H K Smith; M Bradley
Journal:  J Comb Chem       Date:  1999 Jul-Aug

2.  Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

Authors:  S E Salmon; K S Lam; M Lebl; A Kandola; P S Khattri; S Wade; M Pátek; P Kocis; V Krchnák; D Thorpe
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205
  2 in total

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