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Literature DB >> 11377965

Insulin/IGF signalling and ageing: seeing the bigger picture.

Abstract

Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.

Entities: Species

Mesh：

Substances：
Insulin
Somatomedins

Year: 2001 PMID： 11377965 DOI： 10.1016/s0959-437x(00)00192-1

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

28 in total

1. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response.

Authors: Ingo Zinke; Christina S Schütz; Jörg D Katzenberger; Matthias Bauer; Michael J Pankratz
Journal: EMBO J Date: 2002-11-15 Impact factor: 11.598

2. Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Authors: Nick R Leslie; Deborah Bennett; Yvonne E Lindsay; Hazel Stewart; Alex Gray; C Peter Downes
Journal: EMBO J Date: 2003-10-15 Impact factor: 11.598

Review 3. p53, oxidative stress, and aging.

Authors: Dongping Liu; Yang Xu
Journal: Antioxid Redox Signal Date: 2011-02-07 Impact factor: 8.401

Insulin/IGF signalling and ageing: seeing the bigger picture.

1. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response.

2. Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Review 3. p53, oxidative stress, and aging.

4. Anti-ageing strategies: prevention or therapy? Showing ageing from within.

Review 5. Early growth conditions, phenotypic development and environmental change.

Review 6. Dietary restriction and lifespan: Lessons from invertebrate models.

Review 7. Linking Lipid Metabolism to Chromatin Regulation in Aging.

8. Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.

Review 9. Telomeres, stem cells, senescence, and cancer.

10. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet.