Literature DB >> 14722605

Telomeres, stem cells, senescence, and cancer.

Norman E Sharpless1, Ronald A DePinho.   

Abstract

Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.

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Year:  2004        PMID： 14722605      PMCID： PMC311439          DOI： 10.1172/JCI20761

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  123 in total

Review 1.  A critical role for telomeres in suppressing and facilitating carcinogenesis.

Authors:  S E Artandi; R A DePinho
Journal:  Curr Opin Genet Dev       Date:  2000-02       Impact factor: 5.578

2.  Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence.

Authors:  R V Lord; D Salonga; K D Danenberg; J H Peters; T R DeMeester; J M Park; J Johansson; K A Skinner; P Chandrasoma; S R DeMeester; C G Bremner; P I Tsai; P V Danenberg
Journal:  J Gastrointest Surg       Date:  2000 Mar-Apr       Impact factor: 3.452

3.  The effect of longevity on spending for acute and long-term care.

Authors:  B C Spillman; J Lubitz
Journal:  N Engl J Med       Date:  2000-05-11       Impact factor: 91.245

4.  Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

Authors:  E González-Suárez; E Samper; J M Flores; M A Blasco
Journal:  Nat Genet       Date:  2000-09       Impact factor: 38.330

5.  Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences.

Authors:  F M Waldman; S DeVries; K L Chew; D H Moore; K Kerlikowske; B M Ljung
Journal:  J Natl Cancer Inst       Date:  2000-02-16       Impact factor: 13.506

6.  Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes.

Authors:  J D Coursen; W P Bennett; L Gollahon; J W Shay; C C Harris
Journal:  Exp Cell Res       Date:  1997-08-25       Impact factor: 3.905

7.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.

Authors:  S E Artandi; S Chang; S L Lee; S Alson; G J Gottlieb; L Chin; R A DePinho
Journal:  Nature       Date:  2000-08-10       Impact factor: 49.962

8.  Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

Authors:  T Kamijo; F Zindy; M F Roussel; D E Quelle; J R Downing; R A Ashmun; G Grosveld; C J Sherr
Journal:  Cell       Date:  1997-11-28       Impact factor: 41.582

9.  Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

Authors:  M A Blasco; H W Lee; M P Hande; E Samper; P M Lansdorp; R A DePinho; C W Greider
Journal:  Cell       Date:  1997-10-03       Impact factor: 41.582

10.  Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.

Authors:  P R Borghesani; F W Alt; A Bottaro; L Davidson; S Aksoy; G A Rathbun; T M Roberts; W Swat; R A Segal; Y Gu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205
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  149 in total

Review 1.  Using mice to examine p53 functions in cancer, aging, and longevity.

Authors:  Lawrence A Donehower
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-11-04       Impact factor: 10.005

2.  c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

Authors:  Hui-Yi Kua; Huijuan Liu; Wai Fook Leong; Lili Li; Deyong Jia; Gang Ma; Yuanyu Hu; Xueying Wang; Jenny F L Chau; Ye-Guang Chen; Yuji Mishina; Sharon Boast; James Yeh; Li Xia; Guo-Qiang Chen; Lin He; Stephen P Goff; Baojie Li
Journal:  Nat Cell Biol       Date:  2012-06-24       Impact factor: 28.824

Review 3.  Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair.

Authors:  Bin Yao; Sha Huang; Dongyun Gao; Jiangfan Xie; Nanbo Liu; Xiaobing Fu
Journal:  Int Wound J       Date:  2015-10-01       Impact factor: 3.315

Review 4.  Rejuvenation of aged hematopoietic stem cells.

Authors:  Novella Guidi; Hartmut Geiger
Journal:  Semin Hematol       Date:  2016-10-24       Impact factor: 3.851

Review 5.  Therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplantation in lymphoma patients.

Authors:  Mojtaba Akhtari; Vijaya Raj Bhatt; Pavan Kumar Tandra; Jairam Krishnamurthy; Heidi Horstman; Amy Dreessen; Pei Xian Chen; James O Armitage
Journal:  Cancer Biol Ther       Date:  2013-10-18       Impact factor: 4.742

Review 6.  Pathogenesis of pituitary tumors.

Authors:  Shlomo Melmed
Journal:  Nat Rev Endocrinol       Date:  2011-03-22       Impact factor: 43.330

7.  Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways.

Authors:  Karl E Herbert; Yogita Mistry; Richard Hastings; Toryn Poolman; Laura Niklason; Bryan Williams
Journal:  Circ Res       Date:  2007-11-08       Impact factor: 17.367

8.  Increased p53 activity does not accelerate telomere-driven ageing.

Authors:  Isabel García-Cao; Marta García-Cao; Antonia Tomás-Loba; Juan Martín-Caballero; Juana M Flores; Peter Klatt; María A Blasco; Manuel Serrano
Journal:  EMBO Rep       Date:  2006-03-31       Impact factor: 8.807

9.  p63 deficiency activates a program of cellular senescence and leads to accelerated aging.

Authors:  William M Keyes; Ying Wu; Hannes Vogel; Xuecui Guo; Scott W Lowe; Alea A Mills
Journal:  Genes Dev       Date:  2005-08-17       Impact factor: 11.361

Review 10.  Telomere diseases.

Authors:  Rodrigo T Calado; Neal S Young
Journal:  N Engl J Med       Date:  2009-12-10       Impact factor: 91.245
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