| Literature DB >> 11377810 |
T C Rowe1, V Weissig, J W Lawrence.
Abstract
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase gamma and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented.Entities:
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Year: 2001 PMID： 11377810 DOI： 10.1016/s0169-409x(01)00133-8
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470