M Liu1, X Hu, J Liu. 1. Department of Anesthesiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. wuliujin@china.com
Abstract
BACKGROUND:Hypothermia has been shown to decrease the requirement for inhaled anesthetics in animals, but information in humans is limited. METHODS:Thirty-three unpremedicated children with congenital left-to-right shunt heart diseases undergoing open heart surgeries were assigned to one of three groups, with nasopharyngeal temperatures at the time of skin incision of 37, 34, or 31 degrees C. Anesthesia was induced and maintained with isoflurane in oxygen. End-tidal isoflurane concentration and nasopharyngeal temperature were kept at stable levels for at least 15 min before the skin incision. Isoflurane minimum alveolar concentration was determined by using the Dixon up-and-down approach. RESULTS:Isoflurane minimum alveolar concentration values were 1.69 +/- 0.14%, 1.47 +/- 0.10%, and 1.22 +/- 0.15% (mean +/- SD) at 37, 34, and 31 degrees C, respectively. CONCLUSIONS:Hypothermia decreases the isoflurane requirement in children by 5.1 degrees C.
RCT Entities:
BACKGROUND:Hypothermia has been shown to decrease the requirement for inhaled anesthetics in animals, but information in humans is limited. METHODS: Thirty-three unpremedicated children with congenital left-to-right shunt heart diseases undergoing open heart surgeries were assigned to one of three groups, with nasopharyngeal temperatures at the time of skin incision of 37, 34, or 31 degrees C. Anesthesia was induced and maintained with isoflurane in oxygen. End-tidal isoflurane concentration and nasopharyngeal temperature were kept at stable levels for at least 15 min before the skin incision. Isoflurane minimum alveolar concentration was determined by using the Dixon up-and-down approach. RESULTS:Isoflurane minimum alveolar concentration values were 1.69 +/- 0.14%, 1.47 +/- 0.10%, and 1.22 +/- 0.15% (mean +/- SD) at 37, 34, and 31 degrees C, respectively. CONCLUSIONS:Hypothermia decreases the isoflurane requirement in children by 5.1 degrees C.
Authors: Mary Cooter; Katherine Ni; Jake Thomas; Dhanesh K Gupta; Thomas J Hopkins; Timothy E Miller; Michael L James; Miklos D Kertai; Miles Berger Journal: Br J Anaesth Date: 2019-11-01 Impact factor: 9.166
Authors: Dimitry Shnayderman; Michael J Laster; Edmond I Eger; Irene Oh; Yi Zhang; Steven L Jinks; Joseph F Antognini; Douglas E Raines Journal: Anesth Analg Date: 2008-09 Impact factor: 5.108
Authors: Katherine Ni; Mary Cooter; Dhanesh K Gupta; Jake Thomas; Thomas J Hopkins; Timothy E Miller; Michael L James; Miklos D Kertai; Miles Berger Journal: Br J Anaesth Date: 2019-07-03 Impact factor: 9.166