Literature DB >> 11374031

Transcriptional regulation of matrix gla protein.

A Farzaneh-Far1, P L Weissberg, D Proudfoot, C M Shanahan.   

Abstract

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

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Year:  2001        PMID： 11374031     DOI： 10.1007/s003920170040

Source DB:  PubMed          Journal:  Z Kardiol        ISSN： 0300-5860


  14 in total

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