Literature DB >> 11369866

Disulfide structure of alfimeprase: a recombinant analog of fibrolase.

G Jones1, M Ronk, F Mori, Z Zhang.   

Abstract

The disulfide structure of alfimeprase, a recombinant analog of fibrolase, was experimentally determined by a combination of peptide mapping, Edman degradation, and mass spectrometry. The three disulfide bonds were determined to be Cys-116/196, Cys-156 /180, and Cys-158/163 with the residue number system of alfimeprase.

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Year:  2001        PMID： 11369866      PMCID： PMC2374009          DOI： 10.1110/ps.110101

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  7 in total

1.  Biochemical characteristics of fibrolase, a fibrinolytic protease from snake venom.

Authors:  N K Ahmed; K D Tennant; F S Markland; J P Lacz
Journal:  Haemostasis       Date:  1990

2.  A universal algorithm for fast and automated charge state deconvolution of electrospray mass-to-charge ratio spectra.

Authors:  Z Zhang; A G Marshall
Journal:  J Am Soc Mass Spectrom       Date:  1998-03       Impact factor: 3.109

3.  A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems.

Authors:  A D Retzios; F S Markland
Journal:  Thromb Res       Date:  1988-12-15       Impact factor: 3.944

4.  Sequence analysis of fibrolase, a fibrinolytic metalloproteinase from Agkistrodon contortrix contortrix.

Authors:  M C Manning
Journal:  Toxicon       Date:  1995-09       Impact factor: 3.033

5.  Effect of zinc binding on the structure and stability of fibrolase, a fibrinolytic protein from snake venom.

Authors:  D Pretzer; B Schulteis; D G Vander Velde; C D Smith; J W Mitchell; M C Manning
Journal:  Pharm Res       Date:  1992-07       Impact factor: 4.200

6.  Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom.

Authors:  A Randolph; S H Chamberlain; H L Chu; A D Retzios; F S Markland; F R Masiarz
Journal:  Protein Sci       Date:  1992-05       Impact factor: 6.725

7.  Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis.

Authors:  F S Markland; G S Friedrichs; S R Pewitt; B R Lucchesi
Journal:  Circulation       Date:  1994-11       Impact factor: 29.690
  7 in total

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