| Literature DB >> 11369279 |
M Foussard1, S Cabantous, J Pédelacq, V Guillet, S Tranier, L Mourey, C Birck, J Samama.
Abstract
Two-component systems constitute prevalent signaling pathways in bacteria and mediate a large variety of adaptative cellular responses. Signaling proceeds through His-Asp phosphorelay cascades that involve two central partners, the histidine protein kinase and the response regulator protein. Structural studies have provided insights into some design principles and activation mechanisms of these multi-domain proteins implicated in the control of virulence gene expression in several pathogens.Entities:
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Year: 2001 PMID： 11369279 DOI： 10.1016/s1286-4579(01)01390-9
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700