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Literature DB >> 11358688

Cancer chemotherapy--ribonucleases to the rescue.

Abstract

Ribonucleases, once dismissed as uninteresting digestive enzymes, have been shown to have remarkable biological activities. Onconase, from the Northern leopard frog, is currently in clinical trials as a cancer chemotherapeutic. Recent research has revealed some key factors responsible for the cytotoxicity of ribonucleases, and may lead to a new class of drugs.

Entities: Disease Species

Mesh：

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Year: 2001 PMID： 11358688 PMCID： PMC2913432 DOI： 10.1016/s1074-5521(01)00030-8

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

71 in total

1. Ribonuclease A.

Authors: Ronald T. Raines
Journal: Chem Rev Date: 1998-05-07 Impact factor: 60.622

2. Striking sequence similarity among sialic acid-binding lectin, pancreatic ribonucleases, and angiogenin: possible structural and functional relationships.

Authors: M T Lewis; L T Hunt; W C Barker
Journal: Protein Seq Data Anal Date: 1989-02

3. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.

Authors: R Piccoli; S Di Gaetano; C De Lorenzo; M Grauso; C Monaco; D Spalletti-Cernia; P Laccetti; J Cinátl; J Matousek; G D'Alessio
Journal: Proc Natl Acad Sci U S A Date: 1999-07-06 Impact factor: 11.205

4. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A.

Authors: B Kobe; J Deisenhofer
Journal: J Mol Biol Date: 1996-12-20 Impact factor: 5.469

Cancer chemotherapy--ribonucleases to the rescue.

1. Ribonuclease A.

2. Striking sequence similarity among sialic acid-binding lectin, pancreatic ribonucleases, and angiogenin: possible structural and functional relationships.

3. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.

4. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A.

5. Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor.

6. A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity.

7. Comparison of RNases and toxins upon injection into Xenopus oocytes.

Review 8. Cytotoxic ribonucleases and chimeras in cancer therapy.

9. Angiogenin single-chain immunofusions: influence of peptide linkers and spacers between fusion protein domains.

10. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats.

1. Allosteric switching by mutually exclusive folding of protein domains.

2. Creation of a zymogen.

3. Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic.

4. Classical swine fever virus glycoprotein E rns is an endoribonuclease with an unusual base specificity.

5. The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity.

Review 6. Ribonuclease inhibitor: structure and function.

7. Cytotoxic ribonucleases: the dichotomy of Coulombic forces.

8. Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.

9. Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant.

10. Intraspecies regulation of ribonucleolytic activity.