W B van den Berg1. 1. Department of Rheumatology, University Medical Center, Nijmegen, The Netherlands.
Abstract
OBJECTIVE: To update clinicians on recent advances in the differentiation of the mechanisms of inflammation and cartilage destruction in the pathogenesis of rheumatoid arthritis (RA). METHODS: We present analysis of recent published literature and abstracts that elucidates the independent actions of pivotal proinflammatory cytokines. These experimental data provide the framework for understanding the uncoupling of destructive and inflammatory mechanisms in arthritis. RESULTS: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator in the inflammation that occurs in RA. Interleukin-1 (IL-1) has a dominant effect on cartilage destruction that occurs later in the disease process. TNF-independent IL-1 production occurs in many RA model situations. Cytokine balance determines the erosive nature of the disease. CONCLUSION: IL-1 is at least as important as TNF-alpha in promoting the disease process. The pathways by which the inflammatory and destructive changes occur suggest that targeted anticytokine intervention will arrest the cartilage damage that occurs in patients with RA. Copyright 2001 by W.B. Saunders Company.
OBJECTIVE: To update clinicians on recent advances in the differentiation of the mechanisms of inflammation and cartilage destruction in the pathogenesis of rheumatoid arthritis (RA). METHODS: We present analysis of recent published literature and abstracts that elucidates the independent actions of pivotal proinflammatory cytokines. These experimental data provide the framework for understanding the uncoupling of destructive and inflammatory mechanisms in arthritis. RESULTS:Tumor necrosis factor-alpha (TNF-alpha) is an important mediator in the inflammation that occurs in RA. Interleukin-1 (IL-1) has a dominant effect on cartilage destruction that occurs later in the disease process. TNF-independent IL-1 production occurs in many RA model situations. Cytokine balance determines the erosive nature of the disease. CONCLUSION:IL-1 is at least as important as TNF-alpha in promoting the disease process. The pathways by which the inflammatory and destructive changes occur suggest that targeted anticytokine intervention will arrest the cartilage damage that occurs in patients with RA. Copyright 2001 by W.B. Saunders Company.
Authors: C Plater-Zyberk; L A B Joosten; M M A Helsen; J Hepp; P A Baeuerle; W B van den Berg Journal: Ann Rheum Dis Date: 2006-10-04 Impact factor: 19.103
Authors: Andreas Hess; Roland Axmann; Juergen Rech; Stefanie Finzel; Cornelia Heindl; Silke Kreitz; Marina Sergeeva; Marc Saake; Meritxell Garcia; George Kollias; Rainer H Straub; Olaf Sporns; Arnd Doerfler; Kay Brune; Georg Schett Journal: Proc Natl Acad Sci U S A Date: 2011-01-18 Impact factor: 11.205