| Literature DB >> 11354366 |
T M Sielecki1, T L Johnson, J Liu, J K Muckelbauer, R H Grafstrom, S Cox, J Boylan, C R Burton, H Chen, A Smallwood, C H Chang, M Boisclair, P A Benfield, G L Trainor, S P Seitz.
Abstract
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.Entities:
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Year: 2001 PMID： 11354366 DOI： 10.1016/s0960-894x(01)00185-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823