Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.

Literature DB >> 12814430

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.

Katrien Vermeulen¹, Dirk R Van Bockstaele, Zwi N Berneman.

Abstract

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This review will focus on these mechanisms, i.e. regulation of cyclin-dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events. The quality checkpoints activated after DNA damage are also discussed. The complexity of the regulation of the cell cycle is also reflected in the different alterations leading to aberrant cell proliferation and development of cancer. Consequently, targeting the cell cycle in general and CDK in particular presents unique opportunities for drug discovery. This review provides an overview of deregulation of the cell cycle in cancer. Different families of known CDK inhibitors acting by ATP competition are also discussed. Currently, at least three compounds with CDK inhibitory activity (flavopiridol, UCN-01, roscovitine) have entered clinical trials.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2003 PMID： 12814430 PMCID： PMC6496723 DOI： 10.1046/j.1365-2184.2003.00266.x

Source DB: PubMed Journal: Cell Prolif ISSN： 0960-7722 Impact factor: 6.831

174 in total

Review 1. Cyclin-dependent kinase inhibitors and human cancer.

Authors: A Kamb
Journal: Curr Top Microbiol Immunol Date: 1998 Impact factor: 4.291

Review 2. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.

Authors: D J Lew; S Kornbluth
Journal: Curr Opin Cell Biol Date: 1996-12 Impact factor: 8.382

3. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division.

Authors: T Evans; E T Rosenthal; J Youngblom; D Distel; T Hunt
Journal: Cell Date: 1983-06 Impact factor: 41.582

Review 4. Principles of CDK regulation.

Authors: D O Morgan
Journal: Nature Date: 1995-03-09 Impact factor: 49.962

Review 5. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.

Authors: T Hunter; J Pines
Journal: Cell Date: 1994-11-18 Impact factor: 41.582

6. Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.

Authors: K Bojanowski; K Nishio; M Fukuda; A K Larsen; N Saijo
Journal: Biochem Biophys Res Commun Date: 1994-09-30 Impact factor: 3.575

7. Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

Authors: K Grønbaek; T Nedergaard; M K Andersen; P thor Straten; P Guldberg; P Møller; J Zeuthen; N Ebbe Hansen; K Hou-Jensen; E Ralfkiaer
Journal: Leukemia Date: 1998-08 Impact factor: 11.528

8. Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

Authors: J Easton; T Wei; J M Lahti; V J Kidd
Journal: Cancer Res Date: 1998-06-15 Impact factor: 12.701

9. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

Authors: G Fang; H Yu; M W Kirschner
Journal: Genes Dev Date: 1998-06-15 Impact factor: 11.361

10. Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

Authors: I Hoffmann; P R Clarke; M J Marcote; E Karsenti; G Draetta
Journal: EMBO J Date: 1993-01 Impact factor: 11.598

483 in total

1. Antitumor activity of kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice.

Authors: Carlos Rogério Figueiredo; Alisson Leonardo Matsuo; Mariana Hiromi Massaoka; Natalia Girola; Ricardo Alexandre Azevedo; Aline Nogueira Rabaça; Camyla Fernandes Farias; Felipe Valença Pereira; Natalia Silva Matias; Luciana Pereira Silva; Elaine Guadelupe Rodrigues; João Henrique Guilardi Lago; Luiz Rodolpho Travassos; Regildo Márcio Gonçalves Silva
Journal: Adv Pharm Bull Date: 2014-08-25

2. Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes.

Authors: W M Liu; F X Shi; L Z Lu; C Zhang; Y L Liu; J Zhang; Z R Tao; J D Shen; G Q Li; D Q Wang; J J Li; Y Tian
Journal: Mol Cell Biochem Date: 2011-01-28 Impact factor: 3.396

Review 3. Steroid receptors and cell cycle in normal mammary epithelium.

Authors: Elizabeth Anderson; Robert B Clarke
Journal: J Mammary Gland Biol Neoplasia Date: 2004-01 Impact factor: 2.673

4. Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro.

Authors: Jörg Galle; Markus Loeffler; Dirk Drasdo
Journal: Biophys J Date: 2004-10-08 Impact factor: 4.033

5. Genistein at maximal physiologic serum levels induces G0/G1 arrest in MCF-7 and HB4a cells, but not apoptosis.

Authors: Marcela S Tsuboy; Juliana C Marcarini; Alecsandra O de Souza; Natália A de Paula; Daniel J Dorta; Mário S Mantovani; Lucia R Ribeiro
Journal: J Med Food Date: 2013-12-10 Impact factor: 2.786

6. Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells.

Authors: M Montopoli; E Ragazzi; G Froldi; L Caparrotta
Journal: Cell Prolif Date: 2009-02-18 Impact factor: 6.831

7. Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.

Authors: Kyle A Edgar; Marcia Belvin; Annette L Parks; Kellie Whittaker; Matt B Mahoney; Monique Nicoll; Christopher C Park; Christopher G Winter; Feng Chen; Kim Lickteig; Ferhad Ahmad; Hanife Esengil; Matthew V Lorenzi; Amanda Norton; Brent A Rupnow; Laleh Shayesteh; Mariano Tabios; Lynn M Young; Pamela M Carroll; Casey Kopczynski; Gregory D Plowman; Lori S Friedman; Helen L Francis-Lang
Journal: Genetics Date: 2005-03-02 Impact factor: 4.562