| Literature DB >> 1135423 |
P Needleman, S L Key, P C Isakson, P S Kulkarni.
Abstract
In isolated perfused rabbit hearts, coronary vasodilation, produced by reduced oxygen tension seems to be independent of myocardial prostaglandin biosynthesis. a) Anoxia (N2: CO2 95: 5 %) produced coronary vasodilation without causing prostaglandin-like substance (PLS) biosynthesis and release; b) the decrease in coronary resistance during hypoxia (N2:02:CO2 - 80:15:5 %) was sustained during myocardial perfusion with the low oxygen media despite the transitory nature of its PLS release; and c) indomathacin, which abolished basal or ADP stimulated myocardial PLS release, did not abolish the coronary vasodilation produced by ischemia, hypoxia, or anoxia.Entities:
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Year: 1975 PMID： 1135423 DOI： 10.1016/s0090-6980(75)80123-7
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980