Literature DB >> 264662

A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart.

P C Isakson, A Raz, S E Denny, E Pure, P Needleman.   

Abstract

The prostaglandins (PGs) released from the heart have generally been characterized as resembling PGE by bioassay techniques. The major PG formed from [14C]arachidonate (C20:4) by the isolated perfused rabbit heart has chromatographic mobility similar to that of PGE2 in most solvent systems. However, additional analysis of this radioactive "PGE" peak suggests that two substances are formed by the heart and migrate like PGE2: one has chemical properties similar to those of authentic PGE2 and the other is a novel PG. The unknown compound is the major PG formed by the heart from either exogenous arachidonate or hormonal stimulation of PG biosynthesis. The novel PG produced by the heart may be identical with either 6(9)-oxy-PGF or 6-keto-PGF1 alpha.

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Year:  1977        PMID： 264662      PMCID： PMC393205          DOI： 10.1073/pnas.74.1.101

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.

Authors:  K GREEN; B SAMUELSSON
Journal:  J Lipid Res       Date:  1964-01       Impact factor: 5.922

2.  Letter: Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1 alpha in the rat stomach.

Authors:  C Pace-Asciak
Journal:  J Am Chem Soc       Date:  1976-04-14       Impact factor: 15.419

3.  Preparative thin-layer and column chromatography of prostaglandins.

Authors:  N H Anders
Journal:  J Lipid Res       Date:  1969-05       Impact factor: 5.922

4.  Quantitative conversion of PGA or PGE to PGB.

Authors:  R M Zusman
Journal:  Prostaglandins       Date:  1972-02

5.  A novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates.

Authors:  C Pace-Asciak; L S Wolfe
Journal:  Biochemistry       Date:  1971-09-28       Impact factor: 3.162

6.  Phospholipid precursors of prostaglandins.

Authors:  W E Lands; B Samuelsson
Journal:  Biochim Biophys Acta       Date:  1968-10-22

7.  Hormone interactions in the isolated rabbit heart. Synthesis and coronary vasomotor effects of prostaglandins, angiotensin, and bradykinin.

Authors:  P Needleman; G R Marshall; B E Sobel
Journal:  Circ Res       Date:  1975-12       Impact factor: 17.367

8.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962

Review 9.  The synthesis and function of prostaglandins in the heart.

Authors:  P Needleman
Journal:  Fed Proc       Date:  1976-10

10.  Selective incorporation of 14C-arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to 14C-prostaglandins.

Authors:  P C Isakson; A Raz; P Needleman
Journal:  Prostaglandins       Date:  1976-11
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  10 in total

1.  Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.

Authors:  P Needleman; A Raz; M S Minkes; J A Ferrendelli; H Sprecher
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

2.  Release of endothelial mediators and sympathetic transmitters at different coronary flow rates in rabbit hearts.

Authors:  A Wennmalm; G Benthin; E Karwatowska-Prokopczuk; J Lundberg; A S Petersson
Journal:  J Physiol       Date:  1991-04       Impact factor: 5.182

3.  Urinary 6-oxo prostaglandin F1 alpha in myocardial infarction.

Authors:  B R MacDonald; P B Jones; R G Russell; J Radford; J F Martin
Journal:  Br Med J (Clin Res Ed)       Date:  1983-09-10

Review 4.  The prostanoids in hemostasis and thrombosis: a review.

Authors:  J B Smith
Journal:  Am J Pathol       Date:  1980-06       Impact factor: 4.307

5.  Prostaglandin formation from exogenous precursor in homogenates of human cardiac tissue.

Authors:  R Brandt; J Nowak; T Sonnenfeld
Journal:  Basic Res Cardiol       Date:  1984 Mar-Apr       Impact factor: 17.165

6.  Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

Authors:  P Needleman; A Raz; J A Ferrendelli; M Minkes
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

7.  Cardiac and renal prostaglandin I2. Biosynthesis and biological effects in isolated perfused rabbit tissues.

Authors:  P Needleman; S D Bronson; A Wyche; M Sivakoff; K C Nicolaou
Journal:  J Clin Invest       Date:  1978-03       Impact factor: 14.808

8.  Myocardial synthesis of prostaglandin-like substances and coronary reactions to cardiostimulation and to hypoxia.

Authors:  F A Sunahara; J Talesnik
Journal:  Br J Pharmacol       Date:  1979-01       Impact factor: 8.739

9.  Release of two vasodilators, adenosine and prostacyclin, from isolated rabbit hearts during controlled hypoxia.

Authors:  A Edlund; B B Fredholm; P Patrignani; C Patrono; A Wennmalm; M Wennmalm
Journal:  J Physiol       Date:  1983-07       Impact factor: 5.182

10.  Inotropic effect of prostacyclin (PGI2) on isolated rat atria at different contraction frequencies.

Authors:  L Sterin-Borda; L Canga; E S Borda; M F Gimeno; A L Gimeno
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-08       Impact factor: 3.000
  10 in total

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