| Literature DB >> 11353893 |
C Gicquel1, N Boulle, A Logié, N Bourcigaux, V Gaston, Y Le Bouc.
Abstract
Adrenocortical carcinoma remains a challenge for the therapeutist; prognosis is ominous. Various abnormalities playing a pathogenetic role have been recently described in adrenocortical tumors. Among them, dysregulation of the IGF system and imprinting mistakes at the 11p15 locus play a determining role in malignant transformation of adrenocortical cells. These markers of the malignant phenotype might markedly improve our diagnosis and prognosis abilities.Entities:
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Year: 2001 PMID： 11353893
Source DB: PubMed Journal: Ann Endocrinol (Paris) ISSN： 0003-4266 Impact factor: 2.478