Newer therapies for gastroesophageal reflux disease: numb, burn, or stitch?

Preliminary evidence on the efficacy of endoscopically performed interventional techniques for treatment of gastroesophageal reflux disease has emerged in the last year. Three different techniques--radio frequency- induced thermal injury to the gastroesophageal junction, endoscopic plication of gastric folds, and endoscopic implantation of inert polymers into the gastroesophageal junction--have shown promising short-term results. In this review we describe and critically appraise the available published evidence on the efficacy and safety of these techniques. In addition, we discuss clinical and physiologic aspects that are essential for their evaluation and comparison. The need for well-designed controlled clinical trials that assess the long-term efficacy and safety in a wider spectrum of patients is evident, and hopefully such trials are forthcoming. Operator experience and continued evolution in these techniques are likely to be important determinants.