C C Parker1, M Gospodarowicz, P Warde. 1. Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada. christopher.parker@rmp.uhn.on.ca
Abstract
OBJECTIVE: To assess, in a meta-analysis of published studies, whether age influences the behaviour of localized prostate cancer. METHODS: The Medline database was searched from 1966 to 2000 to identify studies analysing the outcome of localized prostate cancer by age, using disease-specific outcome measures, and having controlled for the established prognostic factors of grade, T stage and, where available, serum prostate-specific antigen (PSA) level. RESULTS: In all, 34 studies were identified, which included a total of 27 551 patients. The incomplete and heterogeneous nature of the reports precluded any quantitative overview. The findings of these reports are described and methodological shortcomings discussed. CONCLUSION: The evidence suggests that young age was an adverse prognostic factor in some series of radiation therapy before the advent of PSA assays, when men typically presented clinically with locally advanced disease, but that age has no significant prognostic effect in contemporary series of localized prostate cancer. Possible explanations for this difference are discussed, together with implications for further studies.
OBJECTIVE: To assess, in a meta-analysis of published studies, whether age influences the behaviour of localized prostate cancer. METHODS: The Medline database was searched from 1966 to 2000 to identify studies analysing the outcome of localized prostate cancer by age, using disease-specific outcome measures, and having controlled for the established prognostic factors of grade, T stage and, where available, serum prostate-specific antigen (PSA) level. RESULTS: In all, 34 studies were identified, which included a total of 27 551 patients. The incomplete and heterogeneous nature of the reports precluded any quantitative overview. The findings of these reports are described and methodological shortcomings discussed. CONCLUSION: The evidence suggests that young age was an adverse prognostic factor in some series of radiation therapy before the advent of PSA assays, when men typically presented clinically with locally advanced disease, but that age has no significant prognostic effect in contemporary series of localized prostate cancer. Possible explanations for this difference are discussed, together with implications for further studies.
Authors: Daniel A Hamstra; Kyounghwa Bae; Miljenko V Pilepich; Gerald E Hanks; David J Grignon; David G McGowan; Mack Roach; Colleen Lawton; R Jeffrey Lee; Howard Sandler Journal: Int J Radiat Oncol Biol Phys Date: 2011-03-31 Impact factor: 7.038
Authors: José Arnaldo Shiomi da Cruz; Carlo C Passerotti; Sabrina Thalita Dos Reis; Mary Ellen Salles Guariero; Olimpio Daniel de Campos; Katia Ramos Moreira Leite; Miguel Srougi Journal: Curr Urol Date: 2016-12-26
Authors: Cécile Proust-Lima; Jeremy M G Taylor; Scott G Williams; Donna P Ankerst; Ning Liu; Larry L Kestin; Kyounghwa Bae; Howard M Sandler Journal: Int J Radiat Oncol Biol Phys Date: 2008-11-01 Impact factor: 7.038
Authors: S G Zhao; W C Jackson; V Kothari; M J Schipper; N Erho; J R Evans; C Speers; D A Hamstra; Y S Niknafs; P L Nguyen; E M Schaeffer; A E Ross; R B Den; E A Klein; R B Jenkins; E Davicioni; F Y Feng Journal: Prostate Cancer Prostatic Dis Date: 2015-05-19 Impact factor: 5.554