Literature DB >> 11347252

Influence of methylfenpropidine on growth, sterol content and fatty acid composition of Candida albicans.

J Sajbidor1, E Breierová, M Lamacka, P Bohov.   

Abstract

The effect of methylfenpropidine on growth, lipid contents, sterol and fatty acid composition was investigated in 5 strains of Candida albicans. The sensitivity of the strains decreased in the order: wild strains > erg+ ade nysR > ade nysR erg (defective delta (8-7)-isomerase) > ade nysR erg (defective delta 5-desaturase). The presence of the inhibitor influenced fecosterol isomerization, episterol dehydrogenation, zymosterol transmethylation, ignosterol reduction and squalene epoxidation. Methylfenpropidine also induced changes in fatty acid composition, causing a reduction of the palmitic and oleic acid content with a concomitant elevation of stearic, linoleic and linolenic acid levels. The lipid unsaturation index slightly increased. Morphological changes of wild strains were observed after the fungicide treatment.

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Year:  2000        PMID： 11347252     DOI： 10.1007/bf02817553

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  24 in total

1.  Lipid composition of mesophilic and psychrophilic yeasts (Candida species) as influenced by environmental temperature.

Authors:  M KATES; R M BAXTER
Journal:  Can J Biochem Physiol       Date:  1962-09

2.  Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats.

Authors:  P Bohov; E Seböková; D Gasperíková; P Langer; I Klimes
Journal:  Ann N Y Acad Sci       Date:  1997-09-20       Impact factor: 5.691

3.  Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.

Authors:  K L Jensen-Pergakes; M A Kennedy; N D Lees; R Barbuch; C Koegel; M Bard
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

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Authors:  M Pesti; D Becher; G Bartsch
Journal:  Acta Microbiol Hung       Date:  1983

5.  Protoplast fusion hybrids of Candida albicans sterol mutants differing in nystatin resistance.

Authors:  M Pesti; L Ferenczy
Journal:  J Gen Microbiol       Date:  1982-01

Review 6.  Ergosterol biosynthesis inhibition: a target for antifungal agents.

Authors:  K Barrett-Bee; G Dixon
Journal:  Acta Biochim Pol       Date:  1995       Impact factor: 2.149

7.  Construction and growth properties of a yeast strain defective in sterol 14-reductase.

Authors:  C Marcireau; D Guyonnet; F Karst
Journal:  Curr Genet       Date:  1992-10       Impact factor: 3.886

8.  Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Authors:  B A Arthington; L G Bennett; P L Skatrud; C J Guynn; R J Barbuch; C E Ulbright; M Bard
Journal:  Gene       Date:  1991-06-15       Impact factor: 3.688

9.  Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph.

Authors:  D E Kelly; M E Rose; S L Kelly
Journal:  FEMS Microbiol Lett       Date:  1994-10-01       Impact factor: 2.742

10.  Fenpropimorph affects uptake of uracil and cytosine in Saccharomyces cerevisiae.

Authors:  J H Crowley; R T Lorenz; L W Parks
Journal:  Antimicrob Agents Chemother       Date:  1994-05       Impact factor: 5.191
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