| Literature DB >> 11346465 |
Z Q Yang1, I Imoto, A Pimkhaokham, Y Shimada, K Sasaki, M Oka, J Inazawa.
Abstract
The non-random amplification of DNA at 9p23 - 24 observed in various types of human cancers, including esophageal squamous cell carcinomas (ESCs), may reflect the locations of important tumor-associated genes. Our previous studies using ESC cell lines defined an amplicon in this region and identified a novel gene, GASC1, as a target of the amplification. Since different regions within the same chromosome arm are often involved in amplification in a syntenic or non-syntenic manner, we characterized the amplicon at 9p23 - 24 in 35 ESC cell lines (29 KYSE series and 6 YES series), and examined possible involvement of non-syntenic amplifications at 9p23 - 24 in 32 primary ESCs. Our results clearly indicated that two target regions for DNA amplification exist at 9p23 - 24; the major amplicon contains GASC1, and the minor one harbors a transcription factor, NFIB, centromeric to the GASC1 locus.Entities:
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Year: 2001 PMID： 11346465 PMCID： PMC5926726 DOI： 10.1111/j.1349-7006.2001.tb01112.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050