Pregnancy and infection with human immunodeficiency virus.

During the past decade, there has been a dramatic increase in the number of women infected with HIV and the number of women with clinical AIDS. One of the most prominent features of HIV infection is that it is usually diagnosed during the peak reproductive years, and in 1998, HIV/AIDS was the fourth leading cause of death among women between the ages of 25 and 44 years. For this reason, there has been long-standing concern regarding the obstetric implications of HIV infection: both the impact of pregnancy on possibly accelerating the course of HIV disease and the impact of HIV infection on the course of pregnancy. There appears to be some immunologic changes associated with pregnancy, but they are not dramatic, and immune markers generally resume their prepregnancy values after delivery. With regard to long-term effects of pregnancy on HIV disease progression, no study to date has shown significant increases in mortality or in AIDS incidence associated with pregnancy. Studies have generally been small, however, and none have accounted for antiretroviral therapy usage. Many studies have shown that certain adverse outcomes are more common in HIV-positive pregnant women as compared with HIV-negative pregnant women, and concerns have been raised that spontaneous abortions may be more common among HIV-infected women and that this may impact fertility rates. Although important understanding has been acquired regarding the associations between pregnancy and the course of HIV infection, much remains to be understood. Additional, well-designed studies are clearly needed to rigorously address the many remaining questions that exist. We can anticipate that the resolution of these questions will continue to be of broad public health interest as the epidemic impacts increasing numbers of women, a large fraction of whom will be adolescents.