Literature DB >> 11344311

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.

T Mercher1, M B Coniat, R Monni, M Mauchauffe, F Nguyen Khac, L Gressin, F Mugneret, T Leblanc, N Dastugue, R Berger, O A Bernard.   

Abstract

The recurrent t(1;22)(p13;q13) translocation is exclusively associated with infant acute megakaryoblastic leukemia. We have identified the two genes involved in this translocation. Both genes possess related sequences in the Drosophila genome. The chromosome 22 gene (megakaryocytic acute leukemia, MAL) product is predicted to be involved in chromatin organization, and the chromosome 1 gene (one twenty-two, OTT) product is related to the Drosophila split-end (spen) family of proteins. Drosophila genetic experiments identified spen as involved in connecting the Raf and Hox pathways. Because almost all of the sequences and all of the identified domains of both OTT and MAL proteins are included in the predicted fusion protein, the OTT-MAL fusion could aberrantly modulate chromatin organization, Hox differentiation pathways, or extracellular signaling.

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Year:  2001        PMID： 11344311      PMCID： PMC33289          DOI： 10.1073/pnas.101001498

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein.

Authors:  I Rebay; F Chen; F Hsiao; P A Kolodziej; B H Kuang; T Laverty; C Suh; M Voas; A Williams; G M Rubin
Journal:  Genetics       Date:  2000-02       Impact factor: 4.562

2.  A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.

Authors:  W C Skarnes; B A Auerbach; A L Joyner
Journal:  Genes Dev       Date:  1992-06       Impact factor: 11.361

3.  split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.

Authors:  F Chen; I Rebay
Journal:  Curr Biol       Date:  2000 Jul 27-Aug 10       Impact factor: 10.834

4.  SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.

Authors:  M Kipp; F Göhring; T Ostendorp; C M van Drunen; R van Driel; M Przybylski; F O Fackelmayer
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

5.  In situ hybridization to interphase nuclei in acute leukemia.

Authors:  S P Romana; D Cherif; M Le Coniat; J Derré; M A Flexor; R Berger
Journal:  Genes Chromosomes Cancer       Date:  1993-10       Impact factor: 5.006

6.  Nonrandom t(1;22)(p12-p13;q13) in acute megakaryocytic malignant proliferation.

Authors:  A Baruchel; M T Daniel; G Schaison; R Berger
Journal:  Cancer Genet Cytogenet       Date:  1991-07-15

Review 7.  Rearrangements involving chromosome band 11Q23 in acute leukaemia.

Authors:  J D Rowley
Journal:  Semin Cancer Biol       Date:  1993-12       Impact factor: 15.707

8.  Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study.

Authors:  J E Rubnitz; M P Link; J J Shuster; A J Carroll; N Hakami; L S Frankel; D J Pullen; M L Cleary
Journal:  Blood       Date:  1994-07-15       Impact factor: 22.113

9.  The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study.

Authors:  A Carroll; C Civin; N Schneider; G Dahl; A Pappo; P Bowman; A Emami; S Gross; C Alvarado; C Phillips
Journal:  Blood       Date:  1991-08-01       Impact factor: 22.113

10.  split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo.

Authors:  B Kuang; S C Wu; Y Shin; L Luo; P Kolodziej
Journal:  Development       Date:  2000-04       Impact factor: 6.868
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  89 in total

1.  A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.

Authors:  Mariko Ariyoshi; John W R Schwabe
Journal:  Genes Dev       Date:  2003-08-01       Impact factor: 11.361

2.  Transient abnormal myelopoiesis in a cytogenetically normal neonate.

Authors:  Kentaro Yanase; Keisuke Kato; Nobuko Katayama; Yoko Mouri; Chie Kobayashi; Junko Shiono; Masakazu Abe; Ai Yoshimi; Kazutoshi Koike; Jun-Ichi Arai; Masahiro Tsuchida
Journal:  Int J Hematol       Date:  2010-09-23       Impact factor: 2.490

3.  Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation.

Authors:  Fernando Racimo
Journal:  Genetics       Date:  2015-11-23       Impact factor: 4.562

4.  JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.

Authors:  Thomas Mercher; Gerlinde Wernig; Sandra A Moore; Ross L Levine; Ting-Lei Gu; Stefan Fröhling; Dana Cullen; Roberto D Polakiewicz; Olivier A Bernard; Titus J Boggon; Benjamin H Lee; D Gary Gilliland
Journal:  Blood       Date:  2006-06-27       Impact factor: 22.113

5.  Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

Authors:  Jean-Pierre Bourquin; Aravind Subramanian; Claudia Langebrake; Dirk Reinhardt; Olivier Bernard; Paola Ballerini; André Baruchel; Hélène Cavé; Nicole Dastugue; Henrik Hasle; Gertjan L Kaspers; Michel Lessard; Lucienne Michaux; Paresh Vyas; Elisabeth van Wering; Christian M Zwaan; Todd R Golub; Stuart H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-21       Impact factor: 11.205

6.  The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.

Authors:  Pascal Loyer; Adeline Busson; Janeen H Trembley; Judith Hyle; Jose Grenet; Wei Zhao; Catherine Ribault; Tristan Montier; Vincent J Kidd; Jill M Lahti
Journal:  J Biol Chem       Date:  2010-11-02       Impact factor: 5.157

7.  Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

Authors:  Taisuke Sawada; Chiharu Nishiyama; Takuma Kishi; Tomonari Sasazuki; Sachiko Komazawa-Sakon; Xin Xue; Jiang-Hu Piao; Hideko Ogata; Jun-ichi Nakayama; Tomohiko Taki; Yasuhide Hayashi; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Journal:  J Biol Chem       Date:  2008-07-30       Impact factor: 5.157

8.  Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.

Authors:  Ting Liu; Zhenxing Zhang; Chunjie Yu; Chang Zeng; Xiaoqing Xu; Guixian Wu; Zan Huang; Wenhua Li
Journal:  Br J Pharmacol       Date:  2017-11-02       Impact factor: 8.739

9.  Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation.

Authors:  Elenoe C Smith; Alexandra M Teixeira; Rachel C Chen; Lin Wang; Yuan Gao; Katherine L Hahn; Diane S Krause
Journal:  Blood       Date:  2012-12-14       Impact factor: 22.113

10.  Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.

Authors:  Glen D Raffel; Gerald C Chu; Jonathan L Jesneck; Dana E Cullen; Roderick T Bronson; Olivier A Bernard; D Gary Gilliland
Journal:  Mol Cell Biol       Date:  2008-11-03       Impact factor: 4.272
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