Bakers yeast rises to the challenge: reconstitution of mammalian steroid receptor signalling in S. cerevisiae.

Steroid hormones are an important class of signalling molecule, regulating a diverse range of processes in metazoan eukaryotes. The actions of these hormones are mediated by intracellular receptor proteins that act as ligand-activated transcription factors. The ability to reconstitute steroid receptor signalling in the budding yeast, Saccharomyces cerevisiae, provides a genetically tractable model system in which to investigate steroid receptor structure and function. Through targeted disruption and genetic screening, an increasing number of genes have been identified that are likely to have a role in steroid receptor action.