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Literature DB >> 113345

Antibody-dependent cellular cytotoxicity of Trypanosoma cruzi: characterization of the effector cell from normal human blood.

E D Madeira, A F de Andrade, M M Bunn-Moreno, M Barcinski.

Abstract

The antibody-dependent cellular cytotoxicity activity of normal human blood cells against epimastigotes of Trypanosoma cruzi was measured by the release of incorporated [3H]uridine. Sera from patients with chronic Chagas' disease were used to sensitize the parasites to the lytic activity of the effector cells. Different steps of peripheral blood cell purification were employed, and different cell subpopulations were tested as effectors in the system. The main cytotoxic activity was detected in the granulocyte-rich fraction.

Entities: Chemical Disease Species

Mesh：

Substances：
Antibodies

Year: 1979 PMID： 113345 PMCID： PMC414417 DOI： 10.1128/iai.25.1.34-38.1979

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity.

Authors: D L Nelson; B M Bundy; H E Pitchon; R M Blaese; W Strober
Journal: J Immunol Date: 1976-11 Impact factor: 5.422

2. Eosinophils as mediators of antibody-dependent damage to schistosomula.

Authors: A E Butterworth; R F Sturrock; V Houba; A A Mahmoud; A Sher; P H Rees
Journal: Nature Date: 1975-08-28 Impact factor: 49.962

3. SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.

Authors: A S COULSON; D G CHALMERS
Journal: Lancet Date: 1964-02-29 Impact factor: 79.321

4. Cytotoxicity of antibody-coated trypanosomes by normal human lymphoid cells.

Authors: J B Mkwananzi; D Franks; J R Baker
Journal: Nature Date: 1976-02-05 Impact factor: 49.962

5. Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes.

Authors: C J Sanderson; A F Lopez; M M Moreno
Journal: Nature Date: 1977-07-28 Impact factor: 49.962

6. Antibody-dependent cell-mediated damage to schistosomula in vitro.

Authors: A E Butterworth; R F Sturrock; V Houba; P H Rees
Journal: Nature Date: 1974-12-06 Impact factor: 49.962

7. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

8. Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice.

Authors: A H Greenberg; J H Playfair
Journal: Clin Exp Immunol Date: 1974-01 Impact factor: 4.330

9. Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: the release of tritium-labelled RNA, DNA and protein.

Authors: C J Sanderson; M M Moreno; A F Lopez
Journal: Parasitology Date: 1978-06 Impact factor: 3.234

Antibody-dependent cellular cytotoxicity of Trypanosoma cruzi: characterization of the effector cell from normal human blood.

1. The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity.

2. Eosinophils as mediators of antibody-dependent damage to schistosomula.

3. SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.

4. Cytotoxicity of antibody-coated trypanosomes by normal human lymphoid cells.

5. Eosinophils and not lymphoid K cells kill Trypanosoma cruzi epimastigotes.

6. Antibody-dependent cell-mediated damage to schistosomula in vitro.

7. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

8. Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice.

9. Antibody dependent cell-mediated cytotoxicity of Trypanosoma cruzi: the release of tritium-labelled RNA, DNA and protein.

10. Antibody dependent cell-mediated cytotoxicity against Trypanosoma cruzi.

1. On the mechanism of killing of Trypanosoma cruzi by human polymorphonuclear leukocytes.

2. Trypanosoma theileri: antibody-dependent killing by purified populations of bovine leucocytes.

3. Trypanosoma cruzi: sequence of phagocytosis and cytotoxicity by human polymorphonuclear leucocytes.

4. Trypanosoma cruzi infection in B-cell-deficient rats.

5. Parasitological and immunological aspects of Trypanosoma cruzi infection in nude rats.

6. Delayed hypersensitivity to Trypanosoma cruzi in mice: specific suppressor cells in chronic infection.