Literature DB >> 11333929

Determination of essential amino acids involved in the CD4-independent tropism of the X4 human immunodeficiency virus type 1 m7NDK isolate: role of potential N glycosylations in the C2 and V3 regions of gp120.

J Dumonceaux1, C Goujon, V Joliot, P Briand, U Hazan.   

Abstract

Seven mutations in the C2, V3, and C3 regions of gp120 are implicated in the tropism of the first CD4-independent human immunodeficiency virus type 1 isolate, m7NDK. Site-directed mutagenesis revealed that three amino acids are essential to maintain this tropism, one in the C2 region and two in the V3 loop. Two mutations implied N glycosylation modifications.

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Year:  2001        PMID： 11333929      PMCID： PMC114953          DOI： 10.1128/JVI.75.11.5425-5428.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-03       Impact factor: 11.205

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Authors:  P Catasti; J D Fontenot; E M Bradbury; G Gupta
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  9 in total

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4.  Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.

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Authors:  Bridget A Puffer; Stefan Pöhlmann; Aimee L Edinger; Dan Carlin; Melissa D Sanchez; Julie Reitter; Debbie D Watry; Howard S Fox; Ronald C Desrosiers; Robert W Doms
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6.  Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.

Authors:  Adrienne E Swanstrom; Beth Haggarty; Andrea P O Jordan; Josephine Romano; George J Leslie; Pyone P Aye; Preston A Marx; Andrew A Lackner; Gregory Q Del Prete; James E Robinson; Michael R Betts; David C Montefiori; Celia C LaBranche; James A Hoxie
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7.  Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection.

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9.  Simultaneous determination of five essential amino acids in plasma of Hyperlipidemic subjects by UPLC-MS/MS.

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  9 in total

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