OBJECTIVES: The aim of the study was to assess the prophylactic effect of long-term lithium administration in patients with bipolar mood disorders entering treatment in the 1970s and 1980s at the outpatient clinic of the Department of Psychiatry, University of Medical Sciences, Poznan, Poland. METHODS: The clinical characteristics of two groups of patients before and during lithium therapy were compared, namely, the 60 bipolar patients who entered lithium prophylaxis in the 1970s and 49 patients who entered in the 1980s. Both groups received the drug over a 10-year period. RESULTS: The patients who entered lithium in the 1970s had fewer previous episodes of depression and more of mania than the patients who entered the therapy in the 1980s, although the total number of affective episodes was similar in both groups. The overall prophylactic efficacy of lithium over a 10-year period of administration was similar in both groups, except for a trend towards a greater number of depressive episodes in the first year of lithium prophylaxis in the 1980s group. The excellent lithium responders constituted 35% of the 1970s patients and 27% of those in the 1980s group. The 1970s patients were maintained on a higher level of serum lithium compared to the patients in the 1980s group and had more lithium-induced side effects. CONCLUSIONS: A decrease in lithium prophylactic efficacy in consecutive decades was not observed. Small differences between the bipolar patients entering lithium therapy in the 2 decades were observed in terms of the previous history of illness and during the course of lithium administration.
OBJECTIVES: The aim of the study was to assess the prophylactic effect of long-term lithium administration in patients with bipolar mood disorders entering treatment in the 1970s and 1980s at the outpatient clinic of the Department of Psychiatry, University of Medical Sciences, Poznan, Poland. METHODS: The clinical characteristics of two groups of patients before and during lithium therapy were compared, namely, the 60 bipolarpatients who entered lithium prophylaxis in the 1970s and 49 patients who entered in the 1980s. Both groups received the drug over a 10-year period. RESULTS: The patients who entered lithium in the 1970s had fewer previous episodes of depression and more of mania than the patients who entered the therapy in the 1980s, although the total number of affective episodes was similar in both groups. The overall prophylactic efficacy of lithium over a 10-year period of administration was similar in both groups, except for a trend towards a greater number of depressive episodes in the first year of lithium prophylaxis in the 1980s group. The excellent lithium responders constituted 35% of the 1970s patients and 27% of those in the 1980s group. The 1970s patients were maintained on a higher level of serum lithium compared to the patients in the 1980s group and had more lithium-induced side effects. CONCLUSIONS: A decrease in lithium prophylactic efficacy in consecutive decades was not observed. Small differences between the bipolarpatients entering lithium therapy in the 2 decades were observed in terms of the previous history of illness and during the course of lithium administration.
Authors: Lakshmi N Yatham; Sidney H Kennedy; Sagar V Parikh; Ayal Schaffer; David J Bond; Benicio N Frey; Verinder Sharma; Benjamin I Goldstein; Soham Rej; Serge Beaulieu; Martin Alda; Glenda MacQueen; Roumen V Milev; Arun Ravindran; Claire O'Donovan; Diane McIntosh; Raymond W Lam; Gustavo Vazquez; Flavio Kapczinski; Roger S McIntyre; Jan Kozicky; Shigenobu Kanba; Beny Lafer; Trisha Suppes; Joseph R Calabrese; Eduard Vieta; Gin Malhi; Robert M Post; Michael Berk Journal: Bipolar Disord Date: 2018-03-14 Impact factor: 6.744
Authors: Agnieszka Permoda-Osip; Maria Abramowicz; Agnieszka Kraszewska; Aleksandra Suwalska; Maria Chlopocka-Wozniak; Janusz K Rybakowski Journal: Ther Adv Psychopharmacol Date: 2016-04-17
Authors: Keming Gao; Marzieh Ayati; Mehmet Koyuturk; Joseph R Calabrese; Stephen J Ganocy; Nicholas M Kaye; Hillard M Lazarus; Eric Christian; David Kaplan Journal: Psychopharmacol Bull Date: 2022-02-25
Authors: Anne Berghöfer; Martin Alda; Mazda Adli; Christopher Baethge; Michael Bauer; Tom Bschor; Paul Grof; Bruno Müller-Oerlinghausen; Janusz K Rybakowski; Alexandra Suwalska; Andrea Pfennig Journal: Int J Bipolar Disord Date: 2013-07-31
Authors: Mirko Manchia; Mazda Adli; Nirmala Akula; Raffaella Ardau; Jean-Michel Aubry; Lena Backlund; Claudio Em Banzato; Bernhard T Baune; Frank Bellivier; Susanne Bengesser; Joanna M Biernacka; Clara Brichant-Petitjean; Elise Bui; Cynthia V Calkin; Andrew Tai Ann Cheng; Caterina Chillotti; Sven Cichon; Scott Clark; Piotr M Czerski; Clarissa Dantas; Maria Del Zompo; J Raymond Depaulo; Sevilla D Detera-Wadleigh; Bruno Etain; Peter Falkai; Louise Frisén; Mark A Frye; Jan Fullerton; Sébastien Gard; Julie Garnham; Fernando S Goes; Paul Grof; Oliver Gruber; Ryota Hashimoto; Joanna Hauser; Urs Heilbronner; Rebecca Hoban; Liping Hou; Stéphane Jamain; Jean-Pierre Kahn; Layla Kassem; Tadafumi Kato; John R Kelsoe; Sarah Kittel-Schneider; Sebastian Kliwicki; Po-Hsiu Kuo; Ichiro Kusumi; Gonzalo Laje; Catharina Lavebratt; Marion Leboyer; Susan G Leckband; Carlos A López Jaramillo; Mario Maj; Alain Malafosse; Lina Martinsson; Takuya Masui; Philip B Mitchell; Frank Mondimore; Palmiero Monteleone; Audrey Nallet; Maria Neuner; Tomás Novák; Claire O'Donovan; Urban Osby; Norio Ozaki; Roy H Perlis; Andrea Pfennig; James B Potash; Daniela Reich-Erkelenz; Andreas Reif; Eva Reininghaus; Sara Richardson; Guy A Rouleau; Janusz K Rybakowski; Martin Schalling; Peter R Schofield; Oliver K Schubert; Barbara Schweizer; Florian Seemüller; Maria Grigoroiu-Serbanescu; Giovanni Severino; Lisa R Seymour; Claire Slaney; Jordan W Smoller; Alessio Squassina; Thomas Stamm; Jo Steele; Pavla Stopkova; Sarah K Tighe; Alfonso Tortorella; Gustavo Turecki; Naomi R Wray; Adam Wright; Peter P Zandi; David Zilles; Michael Bauer; Marcella Rietschel; Francis J McMahon; Thomas G Schulze; Martin Alda Journal: PLoS One Date: 2013-06-19 Impact factor: 3.240