Literature DB >> 11327579

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition.

C Michaux1, S Rolin, J M Dogné, F Durant, B Masereel, J Delarge, J Wouters.   

Abstract

BM567, a sulfonylurea compound whose crystal structure is here discussed and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors. In this paper, their crystallographic and electronic structures are compared and lead to new synthesis prospects among the sulfonylurea series.

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Year:  2001        PMID: 11327579     DOI: 10.1016/s0960-894x(01)00114-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Authors:  Slobodan P Rendic; F Peter Guengerich
Journal:  Drug Metab Rev       Date:  2018-08       Impact factor: 4.518

2.  Involvement of the thromboxane A2 receptor in the regulation of steroidogenic acute regulatory gene expression in murine Leydig cells.

Authors:  Akhilesh K Pandey; Xiangling Yin; Randolph B Schiffer; James C Hutson; Douglas M Stocco; Paula Grammas; XingJia Wang
Journal:  Endocrinology       Date:  2009-03-26       Impact factor: 4.736

  2 in total

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