| Literature DB >> 11325217 |
S Karimi1.
Abstract
Several key reactions involving intramolecular cyclization, Grignard reaction, and ionic hydrogenation have been employed in a formal synthesis of sativene. The synthesis affords 3-isopropyl-6-methyltricyclo[4.4.0.0(2,8)]decan-7-one, 12, McMurry's penultimate precursor to sativene, in 28% overall yield in eight steps starting with the commercially available racemic Wieland--Miescher ketone.Entities:
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Year: 2001 PMID： 11325217 DOI： 10.1021/np000550a
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050