| Literature DB >> 11323172 |
P N Schofield1, J A Joyce, W K Lam, V Grandjean, A Ferguson-Smith, W Reik, E R Maher.
Abstract
The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.Entities:
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Year: 2001 PMID： 11323172 DOI： 10.1016/s0378-4274(01)00294-6
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372