| Literature DB >> 11311747 |
M Bös1, A J Sleight, T Godel, J R Martin, C Riemer, H Stadler.
Abstract
RO-04-6790 (6a) has been identified in a random screen for 5-HT(6) receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a logD profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11311747 DOI： 10.1016/s0223-5234(00)01209-5
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514