Literature DB >> 11310606

Synthesis and anti-inflammatory activities of N4,N5-disubstituted-3-methyl- H-pyrazolo[3,4-c]pyridazines.

A K Tewari1, A Mishra.   

Abstract

The synthesis and anti-inflammatory activity of 4,5-dihydroxy-3-methyl-1H-pyrazolo[3,4-c]pyridazine (4), 4,5-dichloro-3-methyl-1H-pyrazolo[3,4-c]pyridazine (5), 4,-benzoyloxy-3-methyl-1-benzoyl-1H-pyrazolo[3,4-c]pyridazin-5yl benzoate (6), 3-methyl-N4,N5-bis(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (7), 4[[5-(4-carboxyanilino)-3-methyl-1H-pyrazolo[3,4-c]pyridazin-4yl]amino]benzoic acid (8), N-[5-(benzoylamino)-3-methyl-1H-pyrazolo[3,4-c]pyridazin-4-yl]benzamide (9) and 3-methyl-N4,N5-bis[4-(1H-benzimidazol-2yl)phenyl]-1H-pyrazolo[3,4-c]pyridazine-4,5-diamine (10) are being reported.

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Year:  2001        PMID： 11310606     DOI： 10.1016/s0968-0896(00)00285-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Erratum to: Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the rat Cerebral Cortex.

Authors:  Julie Lameth; Annie Gervais; Catherine Colin; Philippe Lévêque; Thérèse M Jay; Jean-Marc Edeline; Michel Mallat
Journal:  Neurotox Res       Date:  2017-10       Impact factor: 3.911

2.  Reactivity of pyrazole derivatives with halomethanes: A DFT theoretical study.

Authors:  Monia Chebbi; Youssef Arfaoui
Journal:  J Mol Model       Date:  2018-07-09       Impact factor: 1.810

3.  (E)-4-(2,3-Dihydro-1,3-benzothia-zol-2-yl-idene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Authors:  Imane Chakibe; Abdelfettah Zerzouf; El Mokhtar Essassi; Martin Reichelt; Hans Reuter
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-17

4.  5-Methoxy-methyl-4-phen-oxy-1H-pyrazol-3-ol.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-28

5.  Synthesis, crystal structure, DFT studies and biological activity of (Z)-3-(3-bromophenyl)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxyprop-2-en-1-one.

Authors:  Said Tighadouini; Redouane Benabbes; Monique Tillard; Driss Eddike; Khadija Haboubi; Khalid Karrouchi; Smaail Radi
Journal:  Chem Cent J       Date:  2018-11-26       Impact factor: 4.215

6.  SABRE hyperpolarized anticancer agents for use in 1 H MRI.

Authors:  Elizabeth J Fear; Aneurin J Kennerley; Peter J Rayner; Philip Norcott; Soumya S Roy; Simon B Duckett
Journal:  Magn Reson Med       Date:  2022-03-07       Impact factor: 3.737

7.  Synthesis and quantitative structure-activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents.

Authors:  Wafaa M Abdou; Neven A Ganoub; Eman Sabry
Journal:  Beilstein J Org Chem       Date:  2013-08-22       Impact factor: 2.883

8.  Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines.

Authors:  Yasser Hassan Zaki; Abdelwahed Rashad Sayed; Shaaban A Elroby
Journal:  Chem Cent J       Date:  2016-04-01       Impact factor: 4.215

9.  Experimental and theoretical studies on the functionalization reactions of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid and acid chloride with 2,3-diaminopyridine.

Authors:  Ismail Yildirim; Fatma Kandemirli; Elif Demir
Journal:  Molecules       Date:  2005-03-31       Impact factor: 4.411
  9 in total

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