Literature DB >> 11309528

The role of interleukin-6 in the failing heart.

K C Wollert1, H Drexler.   

Abstract

Clinical studies have shown that circulating levels of interleukin (IL)-6 and other IL-6 related cytokines are increased in patients with congestive heart failure (CHF). Plasma IL-6 concentrations are related to decreasing functional status of the patient and provide important prognostic information. Experimental studies have produced compelling evidence that IL-6 and IL-6 related cytokines play a pivotal role in the regulation of cardiac myocyte hypertrophy and apoptosis. This review summarizes clinical and experimental data from this rapidly evolving field, which, taken together, strongly suggest that IL-6 and IL-6 related cytokines are intricately involved in the pathophysiology of the failing heart.

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Year:  2001        PMID： 11309528     DOI： 10.1023/a:1011401825680

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.214


  62 in total

Review 1.  Angiotensin-converting enzyme inhibitors and cytokines in heart failure: dose and effect?

Authors:  J B Young
Journal:  J Am Coll Cardiol       Date:  1999-12       Impact factor: 24.094

2.  Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure.

Authors:  T Tsutamoto; T Hisanaga; A Wada; K Maeda; M Ohnishi; D Fukai; N Mabuchi; M Sawaki; M Kinoshita
Journal:  J Am Coll Cardiol       Date:  1998-02       Impact factor: 24.094

3.  Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy.

Authors:  J Fukuzawa; G W Booz; R A Hunt; N Shimizu; V Karoor; K M Baker; D E Dostal
Journal:  Hypertension       Date:  2000-06       Impact factor: 10.190

4.  Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure.

Authors:  L Gullestad; P Aukrust; T Ueland; T Espevik; G Yee; R Vagelos; S S Frøland; M Fowler
Journal:  J Am Coll Cardiol       Date:  1999-12       Impact factor: 24.094

5.  beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling.

Authors:  S D Prabhu; B Chandrasekar; D R Murray; G L Freeman
Journal:  Circulation       Date:  2000-05-02       Impact factor: 29.690

6.  Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.

Authors:  K Kunisada; E Tone; Y Fujio; H Matsui; K Yamauchi-Takihara; T Kishimoto
Journal:  Circulation       Date:  1998-07-28       Impact factor: 29.690

7.  Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130.

Authors:  M Narazaki; K Yasukawa; T Saito; Y Ohsugi; H Fukui; Y Koishihara; G D Yancopoulos; T Taga; T Kishimoto
Journal:  Blood       Date:  1993-08-15       Impact factor: 22.113

8.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

Authors:  T Hirano; K Yasukawa; H Harada; T Taga; Y Watanabe; T Matsuda; S Kashiwamura; K Nakajima; K Koyama; A Iwamatsu
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

9.  Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD).

Authors:  G Torre-Amione; S Kapadia; C Benedict; H Oral; J B Young; D L Mann
Journal:  J Am Coll Cardiol       Date:  1996-04       Impact factor: 24.094

10.  The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

Authors:  M Peters; S Jacobs; M Ehlers; P Vollmer; J Müllberg; E Wolf; G Brem; K H Meyer zum Büschenfelde; S Rose-John
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307
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  52 in total

1.  Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

Authors:  Erica M Sparkenbaugh; Pichika Chantrathammachart; Kasemsiri Chandarajoti; Nigel Mackman; Nigel S Key; Rafal Pawlinski
Journal:  Blood       Date:  2016-01-27       Impact factor: 22.113

Review 2.  Reversal of maladaptive gene program in left ventricular myocardium of dogs with heart failure following long-term therapy with the Acorn Cardiac Support Device.

Authors:  Sharad Rastogi; Sudhish Mishra; Ramesh C Gupta; Hani N Sabbah
Journal:  Heart Fail Rev       Date:  2005-06       Impact factor: 4.214

3.  Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts.

Authors:  Meral Urhan Küçük; Nehir Sucu; Seyhan Şahan Firat; Barlas Naim Aytaçoğlu; Özden Vezir; Caner Bozali; Necmiye Canacankatan; Seval Kul; Bahar Tunçtan
Journal:  Eur J Clin Pharmacol       Date:  2014-09-27       Impact factor: 2.953

4.  Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release.

Authors:  D J Brull; J Sanders; A Rumley; G D Lowe; S E Humphries; H E Montgomery
Journal:  Heart       Date:  2002-03       Impact factor: 5.994

Review 5.  Does inflammation affect outcomes in dialysis patients?

Authors:  Kristen L Nowak; Michel Chonchol
Journal:  Semin Dial       Date:  2018-03-07       Impact factor: 3.455

6.  Norepinephrine-induced interleukin-6 increase in rat hearts: differential signal transduction in myocytes and non-myocytes.

Authors:  W Briest; B Rassler; A Deten; M Leicht; R Morwinski; D Neichel; G Wallukat; T Ziegelhöffer; H-G Zimmer
Journal:  Pflugers Arch       Date:  2003-05-06       Impact factor: 3.657

7.  Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.

Authors:  Dan Frenkel; Alok S Pachori; Lunan Zhang; Adi Dembinsky-Vaknin; Dorit Farfara; Sanja Petrovic-Stojkovic; Victor J Dzau; Howard L Weiner
Journal:  Int Immunol       Date:  2009-06-10       Impact factor: 4.823

8.  Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.

Authors:  Yunmei Wang; Jackelyn B Golden; Yi Fritz; Xiufen Zhang; Doina Diaconu; Maya I Camhi; Huiyun Gao; Sean M Dawes; Xianying Xing; Santhi K Ganesh; Johann E Gudjonsson; Daniel I Simon; Thomas S McCormick; Nicole L Ward
Journal:  JCI Insight       Date:  2016-12-08

Review 9.  The varying faces of IL-6: From cardiac protection to cardiac failure.

Authors:  Jillian A Fontes; Noel R Rose; Daniela Čiháková
Journal:  Cytokine       Date:  2015-01-31       Impact factor: 3.861

Review 10.  The immune system and cardiac repair.

Authors:  Nikolaos G Frangogiannis
Journal:  Pharmacol Res       Date:  2008-06-24       Impact factor: 7.658
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